Cell biology of mechanotransduction in inner-ear hair cells

The cloning of deafness genes, especially those for Usher syndrome, has helped to identify a variety of structural proteins involved in the development and function of hair-cell stereocilia. These include novel cadherins, a handful of myosin motors, and scaffolding proteins. Yet a new understanding...

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Detalles Bibliográficos
Autor principal: Corey, David P
Formato: Texto
Lenguaje:English
Publicado: Biology Reports Ltd 2009
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948250/
https://www.ncbi.nlm.nih.gov/pubmed/20948626
http://dx.doi.org/10.3410/B1-58
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author Corey, David P
author_facet Corey, David P
author_sort Corey, David P
collection PubMed
description The cloning of deafness genes, especially those for Usher syndrome, has helped to identify a variety of structural proteins involved in the development and function of hair-cell stereocilia. These include novel cadherins, a handful of myosin motors, and scaffolding proteins. Yet a new understanding of these proteins has upended the orthodox view of mechanosensation by hair cells.
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spelling pubmed-29482502010-10-14 Cell biology of mechanotransduction in inner-ear hair cells Corey, David P F1000 Biol Rep Review Article The cloning of deafness genes, especially those for Usher syndrome, has helped to identify a variety of structural proteins involved in the development and function of hair-cell stereocilia. These include novel cadherins, a handful of myosin motors, and scaffolding proteins. Yet a new understanding of these proteins has upended the orthodox view of mechanosensation by hair cells. Biology Reports Ltd 2009-07-27 /pmc/articles/PMC2948250/ /pubmed/20948626 http://dx.doi.org/10.3410/B1-58 Text en © 2009 Biology Reports Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use this work for commercial purposes
spellingShingle Review Article
Corey, David P
Cell biology of mechanotransduction in inner-ear hair cells
title Cell biology of mechanotransduction in inner-ear hair cells
title_full Cell biology of mechanotransduction in inner-ear hair cells
title_fullStr Cell biology of mechanotransduction in inner-ear hair cells
title_full_unstemmed Cell biology of mechanotransduction in inner-ear hair cells
title_short Cell biology of mechanotransduction in inner-ear hair cells
title_sort cell biology of mechanotransduction in inner-ear hair cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948250/
https://www.ncbi.nlm.nih.gov/pubmed/20948626
http://dx.doi.org/10.3410/B1-58
work_keys_str_mv AT coreydavidp cellbiologyofmechanotransductionininnerearhaircells

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