A current view of Alzheimer's disease

Several genes that influence susceptibility to Alzheimer's disease (AD) have been known for over two decades. Recent advances have elucidated novel candidate genes and the pathogenetic mechanisms underlying neurodegeneration in AD. Here, we summarize what we have learned from studies of the kno...

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Detalles Bibliográficos
Autores principales: Hooli, Basavaraj V, Tanzi, Rudolph E
Formato: Texto
Lenguaje:English
Publicado: Biology Reports Ltd 2009
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948255/
https://www.ncbi.nlm.nih.gov/pubmed/20948630
http://dx.doi.org/10.3410/B1-54
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author Hooli, Basavaraj V
Tanzi, Rudolph E
author_facet Hooli, Basavaraj V
Tanzi, Rudolph E
author_sort Hooli, Basavaraj V
collection PubMed
description Several genes that influence susceptibility to Alzheimer's disease (AD) have been known for over two decades. Recent advances have elucidated novel candidate genes and the pathogenetic mechanisms underlying neurodegeneration in AD. Here, we summarize what we have learned from studies of the known AD genes with regard to the causes of AD and emerging therapies. We also review key recent discoveries that have enhanced our understanding of the etiology and pathogenesis of this devastating disease, based on new investigations into the genes and molecular mechanisms underlying AD.
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spelling pubmed-29482552010-10-14 A current view of Alzheimer's disease Hooli, Basavaraj V Tanzi, Rudolph E F1000 Biol Rep Review Article Several genes that influence susceptibility to Alzheimer's disease (AD) have been known for over two decades. Recent advances have elucidated novel candidate genes and the pathogenetic mechanisms underlying neurodegeneration in AD. Here, we summarize what we have learned from studies of the known AD genes with regard to the causes of AD and emerging therapies. We also review key recent discoveries that have enhanced our understanding of the etiology and pathogenesis of this devastating disease, based on new investigations into the genes and molecular mechanisms underlying AD. Biology Reports Ltd 2009-07-08 /pmc/articles/PMC2948255/ /pubmed/20948630 http://dx.doi.org/10.3410/B1-54 Text en © 2009 Biology Reports Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use this work for commercial purposes
spellingShingle Review Article
Hooli, Basavaraj V
Tanzi, Rudolph E
A current view of Alzheimer's disease
title A current view of Alzheimer's disease
title_full A current view of Alzheimer's disease
title_fullStr A current view of Alzheimer's disease
title_full_unstemmed A current view of Alzheimer's disease
title_short A current view of Alzheimer's disease
title_sort current view of alzheimer's disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948255/
https://www.ncbi.nlm.nih.gov/pubmed/20948630
http://dx.doi.org/10.3410/B1-54
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