Using the ribosome to synthesize peptidomimetics

Peptidomimetic research is an approach to identify peptide-based drugs designed to mimic structural, conformational, and biological properties of peptides while overcoming their limitations, such as protease instability and poor cell penetration. With recent advances in ribosomal synthesis of peptid...

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Detalles Bibliográficos
Autor principal: Freidinger, Roger M
Formato: Texto
Lenguaje:English
Publicado: Biology Reports Ltd 2009
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948258/
https://www.ncbi.nlm.nih.gov/pubmed/20948631
http://dx.doi.org/10.3410/B1-53
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author Freidinger, Roger M
author_facet Freidinger, Roger M
author_sort Freidinger, Roger M
collection PubMed
description Peptidomimetic research is an approach to identify peptide-based drugs designed to mimic structural, conformational, and biological properties of peptides while overcoming their limitations, such as protease instability and poor cell penetration. With recent advances in ribosomal synthesis of peptides containing unnatural amino acids, this technology appears suitable for preparing large structurally diverse libraries of peptidomimetics for drug discovery screening.
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spelling pubmed-29482582010-10-14 Using the ribosome to synthesize peptidomimetics Freidinger, Roger M F1000 Biol Rep Review Article Peptidomimetic research is an approach to identify peptide-based drugs designed to mimic structural, conformational, and biological properties of peptides while overcoming their limitations, such as protease instability and poor cell penetration. With recent advances in ribosomal synthesis of peptides containing unnatural amino acids, this technology appears suitable for preparing large structurally diverse libraries of peptidomimetics for drug discovery screening. Biology Reports Ltd 2009-07-08 /pmc/articles/PMC2948258/ /pubmed/20948631 http://dx.doi.org/10.3410/B1-53 Text en © 2009 Biology Reports Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use this work for commercial purposes
spellingShingle Review Article
Freidinger, Roger M
Using the ribosome to synthesize peptidomimetics
title Using the ribosome to synthesize peptidomimetics
title_full Using the ribosome to synthesize peptidomimetics
title_fullStr Using the ribosome to synthesize peptidomimetics
title_full_unstemmed Using the ribosome to synthesize peptidomimetics
title_short Using the ribosome to synthesize peptidomimetics
title_sort using the ribosome to synthesize peptidomimetics
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948258/
https://www.ncbi.nlm.nih.gov/pubmed/20948631
http://dx.doi.org/10.3410/B1-53
work_keys_str_mv AT freidingerrogerm usingtheribosometosynthesizepeptidomimetics

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