Two mechanisms that account for major histocompatibility complex restriction of T cells

In recent studies, two distinct mechanisms have been proposed to account for major histocompatibility complex (MHC) restriction of T-cell activity: (a) evolution-driven interactions between T-cell receptor (TCR) variable regions and MHC, and (b) a requirement for CD4 or CD8 binding to MHC to initiat...

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Detalles Bibliográficos
Autor principal: Kranz, David M
Formato: Texto
Lenguaje:English
Publicado: Biology Reports Ltd 2009
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948262/
https://www.ncbi.nlm.nih.gov/pubmed/20948629
http://dx.doi.org/10.3410/B1-55
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author Kranz, David M
author_facet Kranz, David M
author_sort Kranz, David M
collection PubMed
description In recent studies, two distinct mechanisms have been proposed to account for major histocompatibility complex (MHC) restriction of T-cell activity: (a) evolution-driven interactions between T-cell receptor (TCR) variable regions and MHC, and (b) a requirement for CD4 or CD8 binding to MHC to initiate signalling through the TCR complex. Both mechanisms are likely to be essential, but for different reasons.
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spelling pubmed-29482622010-10-14 Two mechanisms that account for major histocompatibility complex restriction of T cells Kranz, David M F1000 Biol Rep Review Article In recent studies, two distinct mechanisms have been proposed to account for major histocompatibility complex (MHC) restriction of T-cell activity: (a) evolution-driven interactions between T-cell receptor (TCR) variable regions and MHC, and (b) a requirement for CD4 or CD8 binding to MHC to initiate signalling through the TCR complex. Both mechanisms are likely to be essential, but for different reasons. Biology Reports Ltd 2009-07-27 /pmc/articles/PMC2948262/ /pubmed/20948629 http://dx.doi.org/10.3410/B1-55 Text en © 2009 Biology Reports Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use this work for commercial purposes
spellingShingle Review Article
Kranz, David M
Two mechanisms that account for major histocompatibility complex restriction of T cells
title Two mechanisms that account for major histocompatibility complex restriction of T cells
title_full Two mechanisms that account for major histocompatibility complex restriction of T cells
title_fullStr Two mechanisms that account for major histocompatibility complex restriction of T cells
title_full_unstemmed Two mechanisms that account for major histocompatibility complex restriction of T cells
title_short Two mechanisms that account for major histocompatibility complex restriction of T cells
title_sort two mechanisms that account for major histocompatibility complex restriction of t cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948262/
https://www.ncbi.nlm.nih.gov/pubmed/20948629
http://dx.doi.org/10.3410/B1-55
work_keys_str_mv AT kranzdavidm twomechanismsthataccountformajorhistocompatibilitycomplexrestrictionoftcells

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