Putative functions of caspase-2

Caspase-2 is the most evolutionarily conserved of caspase family members, yet its physiological function has remained unclear and is a matter of considerable debate. Newly published data now suggest that caspase-2 is required for cell cycle regulation, repair of damaged DNA, and in suppressing Myc-i...

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Detalles Bibliográficos
Autores principales: Dorstyn, Loretta, Kumar, Sharad
Formato: Texto
Lenguaje:English
Publicado: Biology Reports 2009
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948275/
https://www.ncbi.nlm.nih.gov/pubmed/20948596
http://dx.doi.org/10.3410/B1-96
Descripción
Sumario:Caspase-2 is the most evolutionarily conserved of caspase family members, yet its physiological function has remained unclear and is a matter of considerable debate. Newly published data now suggest that caspase-2 is required for cell cycle regulation, repair of damaged DNA, and in suppressing Myc-induced lymphomagenesis. Additionally, loss of Casp2 in mice leads to features of premature ageing. These findings suggest that caspase-2 has non-apoptotic functions in addition to its context-dependent roles in cell death.

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