Putative functions of caspase-2

Caspase-2 is the most evolutionarily conserved of caspase family members, yet its physiological function has remained unclear and is a matter of considerable debate. Newly published data now suggest that caspase-2 is required for cell cycle regulation, repair of damaged DNA, and in suppressing Myc-i...

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Detalles Bibliográficos
Autores principales: Dorstyn, Loretta, Kumar, Sharad
Formato: Texto
Lenguaje:English
Publicado: Biology Reports 2009
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948275/
https://www.ncbi.nlm.nih.gov/pubmed/20948596
http://dx.doi.org/10.3410/B1-96
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author Dorstyn, Loretta
Kumar, Sharad
author_facet Dorstyn, Loretta
Kumar, Sharad
author_sort Dorstyn, Loretta
collection PubMed
description Caspase-2 is the most evolutionarily conserved of caspase family members, yet its physiological function has remained unclear and is a matter of considerable debate. Newly published data now suggest that caspase-2 is required for cell cycle regulation, repair of damaged DNA, and in suppressing Myc-induced lymphomagenesis. Additionally, loss of Casp2 in mice leads to features of premature ageing. These findings suggest that caspase-2 has non-apoptotic functions in addition to its context-dependent roles in cell death.
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spelling pubmed-29482752010-10-14 Putative functions of caspase-2 Dorstyn, Loretta Kumar, Sharad F1000 Biol Rep Review Article Caspase-2 is the most evolutionarily conserved of caspase family members, yet its physiological function has remained unclear and is a matter of considerable debate. Newly published data now suggest that caspase-2 is required for cell cycle regulation, repair of damaged DNA, and in suppressing Myc-induced lymphomagenesis. Additionally, loss of Casp2 in mice leads to features of premature ageing. These findings suggest that caspase-2 has non-apoptotic functions in addition to its context-dependent roles in cell death. Biology Reports 2009-12-15 /pmc/articles/PMC2948275/ /pubmed/20948596 http://dx.doi.org/10.3410/B1-96 Text en © 2009 Faculty of 1000 Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use this work for commercial purposes
spellingShingle Review Article
Dorstyn, Loretta
Kumar, Sharad
Putative functions of caspase-2
title Putative functions of caspase-2
title_full Putative functions of caspase-2
title_fullStr Putative functions of caspase-2
title_full_unstemmed Putative functions of caspase-2
title_short Putative functions of caspase-2
title_sort putative functions of caspase-2
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948275/
https://www.ncbi.nlm.nih.gov/pubmed/20948596
http://dx.doi.org/10.3410/B1-96
work_keys_str_mv AT dorstynloretta putativefunctionsofcaspase2
AT kumarsharad putativefunctionsofcaspase2

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