Cargando…

Prediction of function in protein superfamilies

Assignment of function for enzymes encoded in sequenced genomes is a challenging task. Predictions of enzyme function can be made using clues from superfamily assignment, structure, genome context, phylogenetic conservation, and virtual screening to identify potential ligands. Ultimately, confident...

Descripción completa

Detalles Bibliográficos
Autor principal: Copley, Shelley D
Formato: Texto
Lenguaje:English
Publicado: Biology Reports 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948282/
https://www.ncbi.nlm.nih.gov/pubmed/20948600
http://dx.doi.org/10.3410/B1-91
Descripción
Sumario:Assignment of function for enzymes encoded in sequenced genomes is a challenging task. Predictions of enzyme function can be made using clues from superfamily assignment, structure, genome context, phylogenetic conservation, and virtual screening to identify potential ligands. Ultimately, confident assignment of function requires experimental verification as well as an understanding of the physiological role of an enzyme in the context of the metabolic network.