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Prediction of function in protein superfamilies
Assignment of function for enzymes encoded in sequenced genomes is a challenging task. Predictions of enzyme function can be made using clues from superfamily assignment, structure, genome context, phylogenetic conservation, and virtual screening to identify potential ligands. Ultimately, confident...
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Formato: | Texto |
Lenguaje: | English |
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Biology Reports
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948282/ https://www.ncbi.nlm.nih.gov/pubmed/20948600 http://dx.doi.org/10.3410/B1-91 |
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author | Copley, Shelley D |
author_facet | Copley, Shelley D |
author_sort | Copley, Shelley D |
collection | PubMed |
description | Assignment of function for enzymes encoded in sequenced genomes is a challenging task. Predictions of enzyme function can be made using clues from superfamily assignment, structure, genome context, phylogenetic conservation, and virtual screening to identify potential ligands. Ultimately, confident assignment of function requires experimental verification as well as an understanding of the physiological role of an enzyme in the context of the metabolic network. |
format | Text |
id | pubmed-2948282 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Biology Reports |
record_format | MEDLINE/PubMed |
spelling | pubmed-29482822010-10-14 Prediction of function in protein superfamilies Copley, Shelley D F1000 Biol Rep Review Article Assignment of function for enzymes encoded in sequenced genomes is a challenging task. Predictions of enzyme function can be made using clues from superfamily assignment, structure, genome context, phylogenetic conservation, and virtual screening to identify potential ligands. Ultimately, confident assignment of function requires experimental verification as well as an understanding of the physiological role of an enzyme in the context of the metabolic network. Biology Reports 2009-12-09 /pmc/articles/PMC2948282/ /pubmed/20948600 http://dx.doi.org/10.3410/B1-91 Text en © 2009 Faculty of 1000 Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use this work for commercial purposes |
spellingShingle | Review Article Copley, Shelley D Prediction of function in protein superfamilies |
title | Prediction of function in protein superfamilies |
title_full | Prediction of function in protein superfamilies |
title_fullStr | Prediction of function in protein superfamilies |
title_full_unstemmed | Prediction of function in protein superfamilies |
title_short | Prediction of function in protein superfamilies |
title_sort | prediction of function in protein superfamilies |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948282/ https://www.ncbi.nlm.nih.gov/pubmed/20948600 http://dx.doi.org/10.3410/B1-91 |
work_keys_str_mv | AT copleyshelleyd predictionoffunctioninproteinsuperfamilies |