Prediction of function in protein superfamilies

Assignment of function for enzymes encoded in sequenced genomes is a challenging task. Predictions of enzyme function can be made using clues from superfamily assignment, structure, genome context, phylogenetic conservation, and virtual screening to identify potential ligands. Ultimately, confident...

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Detalles Bibliográficos
Autor principal: Copley, Shelley D
Formato: Texto
Lenguaje:English
Publicado: Biology Reports 2009
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948282/
https://www.ncbi.nlm.nih.gov/pubmed/20948600
http://dx.doi.org/10.3410/B1-91
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author Copley, Shelley D
author_facet Copley, Shelley D
author_sort Copley, Shelley D
collection PubMed
description Assignment of function for enzymes encoded in sequenced genomes is a challenging task. Predictions of enzyme function can be made using clues from superfamily assignment, structure, genome context, phylogenetic conservation, and virtual screening to identify potential ligands. Ultimately, confident assignment of function requires experimental verification as well as an understanding of the physiological role of an enzyme in the context of the metabolic network.
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spelling pubmed-29482822010-10-14 Prediction of function in protein superfamilies Copley, Shelley D F1000 Biol Rep Review Article Assignment of function for enzymes encoded in sequenced genomes is a challenging task. Predictions of enzyme function can be made using clues from superfamily assignment, structure, genome context, phylogenetic conservation, and virtual screening to identify potential ligands. Ultimately, confident assignment of function requires experimental verification as well as an understanding of the physiological role of an enzyme in the context of the metabolic network. Biology Reports 2009-12-09 /pmc/articles/PMC2948282/ /pubmed/20948600 http://dx.doi.org/10.3410/B1-91 Text en © 2009 Faculty of 1000 Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use this work for commercial purposes
spellingShingle Review Article
Copley, Shelley D
Prediction of function in protein superfamilies
title Prediction of function in protein superfamilies
title_full Prediction of function in protein superfamilies
title_fullStr Prediction of function in protein superfamilies
title_full_unstemmed Prediction of function in protein superfamilies
title_short Prediction of function in protein superfamilies
title_sort prediction of function in protein superfamilies
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948282/
https://www.ncbi.nlm.nih.gov/pubmed/20948600
http://dx.doi.org/10.3410/B1-91
work_keys_str_mv AT copleyshelleyd predictionoffunctioninproteinsuperfamilies

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