Factors affecting prognosis in myelofibrosis

Studies investigating factors affecting prognosis in primary myelofibrosis have been numerous over the years because of the high heterogeneity with regard to its natural clinical course. Recently, the increasing application of reduced-intensity conditioning with allogeneic hematopoietic stem cell transplantation as well as the ongoing rapid development of new experimental agents, such as JAK2 inhibitors, have made the requirement for simple and accurate scoring systems to select individual patients for the most appropriate treatment strategy even more critical. This short report summarizes the state of the art and the most recent advances in this area.