Management of infections due to KPC-producing Klebsiella pneumoniae

The emergence of the Klebsiella pneumoniae carbapenemases in K. pneumoniae and other Gram-negative bacteria, usually on a background of multidrug resistance, has led to difficult therapeutic choices. Among available antibiotics, tigecycline and the polymyxins are the most frequently active against t...

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Detalles Bibliográficos
Autores principales: Deresinski, Stanley C, Schirmer, Patricia
Formato: Texto
Lenguaje:English
Publicado: Medicine Reports Ltd 2009
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948324/
https://www.ncbi.nlm.nih.gov/pubmed/20948700
http://dx.doi.org/10.3410/M1-79
Descripción
Sumario:The emergence of the Klebsiella pneumoniae carbapenemases in K. pneumoniae and other Gram-negative bacteria, usually on a background of multidrug resistance, has led to difficult therapeutic choices. Among available antibiotics, tigecycline and the polymyxins are the most frequently active against these organisms in vitro. Optimal therapy of infections due to these bacteria may involve maximization of antibiotic dose as well as their use in combination.

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