LOV conquers (sm)All GTPases

Knowledge of spatial patterning of GTPases is critical to understanding protein function since subcellular localization is essential for normal protein function. In this paper, we discuss how Hahn’s group has created a new type of genetically encoded, light-activated enzyme that allows precise tempo...

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Detalles Bibliográficos
Autores principales: Kosoff, Rachelle, Chernoff, Jonathan
Formato: Texto
Lenguaje:English
Publicado: Faculty of 1000 Ltd 2010
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948368/
https://www.ncbi.nlm.nih.gov/pubmed/20948805
http://dx.doi.org/10.3410/B2-28
Descripción
Sumario:Knowledge of spatial patterning of GTPases is critical to understanding protein function since subcellular localization is essential for normal protein function. In this paper, we discuss how Hahn’s group has created a new type of genetically encoded, light-activated enzyme that allows precise temporal and spatial control of the small GTPase, Rac1. This reagent enables this group to analyze the roles of effector proteins in Rac1 function and may be applicable to other signaling proteins.

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