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LOV conquers (sm)All GTPases

Knowledge of spatial patterning of GTPases is critical to understanding protein function since subcellular localization is essential for normal protein function. In this paper, we discuss how Hahn’s group has created a new type of genetically encoded, light-activated enzyme that allows precise tempo...

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Detalles Bibliográficos
Autores principales: Kosoff, Rachelle, Chernoff, Jonathan
Formato: Texto
Lenguaje:English
Publicado: Faculty of 1000 Ltd 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948368/
https://www.ncbi.nlm.nih.gov/pubmed/20948805
http://dx.doi.org/10.3410/B2-28
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author Kosoff, Rachelle
Chernoff, Jonathan
author_facet Kosoff, Rachelle
Chernoff, Jonathan
author_sort Kosoff, Rachelle
collection PubMed
description Knowledge of spatial patterning of GTPases is critical to understanding protein function since subcellular localization is essential for normal protein function. In this paper, we discuss how Hahn’s group has created a new type of genetically encoded, light-activated enzyme that allows precise temporal and spatial control of the small GTPase, Rac1. This reagent enables this group to analyze the roles of effector proteins in Rac1 function and may be applicable to other signaling proteins.
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spelling pubmed-29483682010-10-14 LOV conquers (sm)All GTPases Kosoff, Rachelle Chernoff, Jonathan F1000 Biol Rep Review Article Knowledge of spatial patterning of GTPases is critical to understanding protein function since subcellular localization is essential for normal protein function. In this paper, we discuss how Hahn’s group has created a new type of genetically encoded, light-activated enzyme that allows precise temporal and spatial control of the small GTPase, Rac1. This reagent enables this group to analyze the roles of effector proteins in Rac1 function and may be applicable to other signaling proteins. Faculty of 1000 Ltd 2010-04-12 /pmc/articles/PMC2948368/ /pubmed/20948805 http://dx.doi.org/10.3410/B2-28 Text en © 2010 Faculty of 1000 Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use this work for commercial purposes
spellingShingle Review Article
Kosoff, Rachelle
Chernoff, Jonathan
LOV conquers (sm)All GTPases
title LOV conquers (sm)All GTPases
title_full LOV conquers (sm)All GTPases
title_fullStr LOV conquers (sm)All GTPases
title_full_unstemmed LOV conquers (sm)All GTPases
title_short LOV conquers (sm)All GTPases
title_sort lov conquers (sm)all gtpases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948368/
https://www.ncbi.nlm.nih.gov/pubmed/20948805
http://dx.doi.org/10.3410/B2-28
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