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LOV conquers (sm)All GTPases
Knowledge of spatial patterning of GTPases is critical to understanding protein function since subcellular localization is essential for normal protein function. In this paper, we discuss how Hahn’s group has created a new type of genetically encoded, light-activated enzyme that allows precise tempo...
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Formato: | Texto |
Lenguaje: | English |
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Faculty of 1000 Ltd
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948368/ https://www.ncbi.nlm.nih.gov/pubmed/20948805 http://dx.doi.org/10.3410/B2-28 |
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author | Kosoff, Rachelle Chernoff, Jonathan |
author_facet | Kosoff, Rachelle Chernoff, Jonathan |
author_sort | Kosoff, Rachelle |
collection | PubMed |
description | Knowledge of spatial patterning of GTPases is critical to understanding protein function since subcellular localization is essential for normal protein function. In this paper, we discuss how Hahn’s group has created a new type of genetically encoded, light-activated enzyme that allows precise temporal and spatial control of the small GTPase, Rac1. This reagent enables this group to analyze the roles of effector proteins in Rac1 function and may be applicable to other signaling proteins. |
format | Text |
id | pubmed-2948368 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Faculty of 1000 Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-29483682010-10-14 LOV conquers (sm)All GTPases Kosoff, Rachelle Chernoff, Jonathan F1000 Biol Rep Review Article Knowledge of spatial patterning of GTPases is critical to understanding protein function since subcellular localization is essential for normal protein function. In this paper, we discuss how Hahn’s group has created a new type of genetically encoded, light-activated enzyme that allows precise temporal and spatial control of the small GTPase, Rac1. This reagent enables this group to analyze the roles of effector proteins in Rac1 function and may be applicable to other signaling proteins. Faculty of 1000 Ltd 2010-04-12 /pmc/articles/PMC2948368/ /pubmed/20948805 http://dx.doi.org/10.3410/B2-28 Text en © 2010 Faculty of 1000 Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use this work for commercial purposes |
spellingShingle | Review Article Kosoff, Rachelle Chernoff, Jonathan LOV conquers (sm)All GTPases |
title | LOV conquers (sm)All GTPases |
title_full | LOV conquers (sm)All GTPases |
title_fullStr | LOV conquers (sm)All GTPases |
title_full_unstemmed | LOV conquers (sm)All GTPases |
title_short | LOV conquers (sm)All GTPases |
title_sort | lov conquers (sm)all gtpases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948368/ https://www.ncbi.nlm.nih.gov/pubmed/20948805 http://dx.doi.org/10.3410/B2-28 |
work_keys_str_mv | AT kosoffrachelle lovconquerssmallgtpases AT chernoffjonathan lovconquerssmallgtpases |