Deletion at chromosome arm 9p in relation to BRAF/NRAS mutations and prognostic significance for primary melanoma

We report an investigation of gene dosage at 9p21.3 and mutations in BRAF and NRAS, as predictors of relapse and histological markers of poor melanoma prognosis. Formalin-fixed primary melanomas from 74 relapsed and 42 nonrelapsed patients were sequenced for common BRAF and NRAS mutations (N = 71 re...

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Detalles Bibliográficos
Autores principales: Conway, Caroline, Beswick, Samantha, Elliott, Faye, Chang, Yu-Mei, Randerson-Moor, Juliette, Harland, Mark, Affleck, Paul, Marsden, Jerry, Sanders, D Scott, Boon, Andy, Knowles, Margaret A, Bishop, D Timothy, Newton-Bishop, Julia A
Formato: Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948432/
https://www.ncbi.nlm.nih.gov/pubmed/20140953
http://dx.doi.org/10.1002/gcc.20753

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