Cargando…

The Anti-Inflammatory Drug Leflunomide Is an Agonist of the Aryl Hydrocarbon Receptor

BACKGROUND: The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the toxicity and biological activity of dioxins and related chemicals. The AhR influences a variety of processes involved in cellular growth and differentiation, and recent studies have suggested...

Descripción completa

Detalles Bibliográficos
Autores principales:	O'Donnell, Edmond F., Saili, Katerine S., Koch, Daniel C., Kopparapu, Prasad R., Farrer, David, Bisson, William H., Mathew, Lijoy K., Sengupta, Sumitra, Kerkvliet, Nancy I., Tanguay, Robert L., Kolluri, Siva Kumar
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948512/ https://www.ncbi.nlm.nih.gov/pubmed/20957046 http://dx.doi.org/10.1371/journal.pone.0013128

Ejemplares similares

The Aryl Hydrocarbon Receptor Mediates Leflunomide-Induced Growth Inhibition of Melanoma Cells
por: O’Donnell, Edmond F., et al.
Publicado: (2012)

A Structural Switch between Agonist and Antagonist Bound Conformations for a Ligand-Optimized Model of the Human Aryl Hydrocarbon Receptor Ligand Binding Domain
por: Perkins, Arden, et al.
Publicado: (2014)

The aryl hydrocarbon receptor is required for induction of p21(cip1/waf1) expression and growth inhibition by SU5416 in hepatoma cells
por: O’Donnell, Edmond F., et al.
Publicado: (2017)

Benzimidazoisoquinolines: A New Class of Rapidly Metabolized Aryl Hydrocarbon Receptor (AhR) Ligands that Induce AhR-Dependent Tregs and Prevent Murine Graft-Versus-Host Disease
por: Punj, Sumit, et al.
Publicado: (2014)

The aryl hydrocarbon receptor mediates raloxifene-induced apoptosis in estrogen receptor-negative hepatoma and breast cancer cells
por: O'Donnell, E F, et al.
Publicado: (2014)

Identification of a Raloxifene Analog That Promotes AhR-Mediated Apoptosis in Cancer Cells
por: Jang, Hyo Sang, et al.
Publicado: (2017)

Tumor-Suppressive Functions of the Aryl Hydrocarbon Receptor (AhR) and AhR as a Therapeutic Target in Cancer
por: Elson, Daniel J., et al.
Publicado: (2023)

AHR2 Mutant Reveals Functional Diversity of Aryl Hydrocarbon Receptors in Zebrafish
por: Goodale, Britton C., et al.
Publicado: (2012)

Detection of aryl hydrocarbon receptor agonists in human samples
por: Rothhammer, Veit, et al.
Publicado: (2018)

Induction of apoptosis and suppression of tumor growth by Nur77-derived Bcl-2 converting peptide in chemoresistant lung cancer cells
por: Pearce, Martin C., et al.
Publicado: (2018)

Dynamic regulation of serum aryl hydrocarbon receptor agonists in MS
por: Rothhammer, Veit, et al.
Publicado: (2017)

Discovery of 2-aryl and 2-pyridinylbenzothiazoles endowed with antimicrobial and aryl hydrocarbon receptor agonistic activities
por: Goya-Jorge, Elizabeth, et al.
Publicado: (2020)

Glucocorticoid receptor-dependent induction of cripto-1 (one-eyed pinhead) inhibits zebrafish caudal fin regeneration
por: Garland, Michael A., et al.
Publicado: (2019)

Aryl Hydrocarbon Receptor-Mediated Perturbations in Gene Expression during Early Stages of CD4(+) T-cell Differentiation
por: Rohlman, Diana, et al.
Publicado: (2012)

Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context.
por: Zhang, Shu, et al.
Publicado: (2003)

Lineage-dependent effects of aryl hydrocarbon receptor agonists contribute to liver tumorigenesis
por: Harrill, Joshua A, et al.
Publicado: (2015)

Characterization of Natural Aryl Hydrocarbon Receptor Agonists from Cassia Seed and Rosemary
por: Amakura, Yoshiaki, et al.
Publicado: (2014)

Vitiligo responds to topical aryl hydrocarbon receptor agonist tapinarof (WBI-1001)
por: Liu, Lisa, et al.
Publicado: (2023)

Generalized Concentration Addition Predicts Joint Effects of Aryl Hydrocarbon Receptor Agonists with Partial Agonists and Competitive Antagonists
por: Howard, Gregory J., et al.
Publicado: (2010)

Novel Aryl Hydrocarbon Receptor Agonist Suppresses Migration and Invasion of Breast Cancer Cells
por: Hanieh, Hamza, et al.
Publicado: (2016)

Activation of aryl hydrocarbon receptor signaling by a novel agonist ameliorates autoimmune encephalomyelitis
por: Abdullah, Alzahrani, et al.
Publicado: (2019)

Aryl Hydrocarbon Receptor Plasma Agonist Activity Correlates With Disease Activity in Progressive MS
por: Tsaktanis, Thanos, et al.
Publicado: (2020)

Aryl Hydrocarbon Receptor Agonist VAF347 Impedes Retinal Pathogenesis in Diabetic Mice
por: Zapadka, Thomas E., et al.
Publicado: (2021)

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles
por: Hubbard, Troy D., et al.
Publicado: (2015)

Synergistic Embryotoxicity of Polycyclic Aromatic Hydrocarbon Aryl Hydrocarbon Receptor Agonists with Cytochrome P4501A Inhibitors in Fundulus heteroclitus
por: Wassenberg, Deena M., et al.
Publicado: (2004)

Gut Microbial Catabolites of Tryptophan Are Ligands and Agonists of the Aryl Hydrocarbon Receptor: A Detailed Characterization
por: Vyhlídalová, Barbora, et al.
Publicado: (2020)

Correction: Activation of aryl hydrocarbon receptor signaling by a novel agonist ameliorates autoimmune encephalomyelitis
Publicado: (2019)

Modulation of lymphocyte-mediated tissue repair by rational design of heterocyclic aryl hydrocarbon receptor agonists
por: Chen, Jiaxuan, et al.
Publicado: (2020)

Involvement of Aryl Hydrocarbon Receptor and Aryl Hydrocarbon Receptor Repressor in Helicobacter Pylori-related Gastric Pathogenesis
por: Zhu, Renfei, et al.
Publicado: (2018)

The flavonoid galangin is an inhibitor of CYP1A1 activity and an agonist/antagonist of the aryl hydrocarbon receptor
por: Ciolino, H P, et al.
Publicado: (1999)

Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells
por: Veldhoen, Marc, et al.
Publicado: (2009)

Breast Cancer Stem-Like Cells Are Inhibited by a Non-Toxic Aryl Hydrocarbon Receptor Agonist
por: Prud'homme, Gérald J., et al.
Publicado: (2010)

The aryl hydrocarbon receptor in tumor immunity
por: Platten, Michael, et al.
Publicado: (2012)

Antioxidant Functions of the Aryl Hydrocarbon Receptor
por: Dietrich, Cornelia
Publicado: (2016)

Aryl Hydrocarbon Receptor and Stem Cells
por: Gasiewicz, Thomas A., et al.
Publicado: (2017)

The Aryl Hydrocarbon Receptor and Tumor Immunity
por: Xue, Ping, et al.
Publicado: (2018)

The Aryl Hydrocarbon Receptor and the Nervous System
por: Juricek, Ludmila, et al.
Publicado: (2018)

The aryl hydrocarbon receptor in liver inflammation
por: Carambia, Antonella, et al.
Publicado: (2021)

Activation of the aryl hydrocarbon receptor inhibits neuropilin-1 upregulation on IL-2-responding CD4(+) T cells
por: Sandoval, Simone, et al.
Publicado: (2023)

Melatonin and Its Metabolites Can Serve as Agonists on the Aryl Hydrocarbon Receptor and Peroxisome Proliferator-Activated Receptor Gamma
por: Slominski, Andrzej T., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_fn3848uceicvvd7uqop7idgbbe