Cargando…

Human β-defensin 3 has immunosuppressive activity in vitro and in vivo

β-defensins are antimicrobial peptides with an essential role in the innate immune response. In addition β-defensins can also chemoattract cells involved in adaptive immunity. Until now, based on evidence from dendritic cell stimulation, human β defensin-3 (hBD3) was considered pro-inflammatory. We...

Descripción completa

Detalles Bibliográficos
Autores principales:	Semple, Fiona, Webb, Sheila, Li, Hsin-Ni, Patel, Hetal B, Perretti, Mauro, Jackson, Ian J, Gray, Mohini, Davidson, Donald J, Dorin, Julia R
Formato:	Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2010
Materias:	Immunomodulation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948537/ https://www.ncbi.nlm.nih.gov/pubmed/20104491 http://dx.doi.org/10.1002/eji.200940041

Ejemplares similares

Human β-defensin 3 affects the activity of pro-inflammatory pathways associated with MyD88 and TRIF
por: Semple, Fiona, et al.
Publicado: (2011)

Induction of transplantation tolerance converts potential effector T cells into graft-protective regulatory T cells
por: Francis, Ross S, et al.
Publicado: (2011)

Regulatory T cells can prevent memory CD8(+) T-cell-mediated rejection following polymorphonuclear cell depletion
por: Jones, Nick D, et al.
Publicado: (2010)

Exogenous IFN-γ ex vivo shapes the alloreactive T-cell repertoire by inhibition of Th17 responses and generation of functional Foxp3(+) regulatory T cells
por: Feng, Gang, et al.
Publicado: (2008)

Anti-CD4-mediated selection of Treg in vitro – in vitro suppression does not predict in vivo capacity to prevent graft rejection
por: Oliveira, Vanessa, et al.
Publicado: (2008)

Arginine depletion as a mechanism for the immune privilege of corneal allografts
por: Fu, Hongmei, et al.
Publicado: (2011)

Exacerbated experimental arthritis in Wiskott–Aldrich syndrome protein deficiency: Modulatory role of regulatory B cells
por: Bouma, Gerben, et al.
Publicado: (2014)

Dendritic cell modification as a route to inhibiting corneal graft rejection by the indirect pathway of allorecognition
por: Khan, Adnan, et al.
Publicado: (2013)

Regulatory T cells inhibit Fas ligand-induced innate and adaptive tumour immunity
por: Simon, Anna Katharina, et al.
Publicado: (2007)

Absence of Rac1 and Rac3 GTPases in the nervous system hinders thymic, splenic and immune-competence development
por: Basso, Veronica, et al.
Publicado: (2011)

Killing of myeloid APCs via HLA class I, CD2 and CD226 defines a novel mechanism of suppression by human Tr1 cells
por: Magnani, Chiara F, et al.
Publicado: (2011)

HIV-1 impairs in vitro priming of naïve T cells and gives rise to contact-dependent suppressor T cells
por: Che, Karlhans F, et al.
Publicado: (2010)

Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region
por: Wooldridge, Linda, et al.
Publicado: (2007)

A homodimeric complex of HLA-G on normal trophoblast cells modulates antigen-presenting cells via LILRB1
por: Apps, Richard, et al.
Publicado: (2007)

Granulocyte-colony stimulating factor drives the in vitro differentiation of human dendritic cells that induce anergy in naïve T cells
por: Rossetti, Maura, et al.
Publicado: (2010)

PD-1 modulates steady-state and infection-induced IL-10 production in vivo
por: McBerry, Cortez, et al.
Publicado: (2014)

IL-33 attenuates the development of experimental autoimmune uveitis
por: Barbour, Mark, et al.
Publicado: (2014)

Glycogen synthase kinase-3 controls IL-10 expression in CD4(+) effector T-cell subsets through epigenetic modification of the IL-10 promoter
por: Hill, Elaine V, et al.
Publicado: (2015)

IL‐12/15/18‐preactivated NK cells suppress GvHD in a mouse model of mismatched hematopoietic cell transplantation
por: Hüber, Christian M., et al.
Publicado: (2015)

OX40 controls effector CD4(+) T-cell expansion, not follicular T helper cell generation in acute Listeria infection
por: Marriott, Clare L, et al.
Publicado: (2014)

Progesterone promotes maternal–fetal tolerance by reducing human maternal T‐cell polyfunctionality and inducing a specific cytokine profile
por: Lissauer, David, et al.
Publicado: (2015)

HLA class I downregulation is associated with enhanced NK‐cell killing of melanoma cells with acquired drug resistance to BRAF inhibitors
por: Sottile, Rosa, et al.
Publicado: (2015)

Exposure to inflammatory cytokines selectively limits GM-CSF production by induced T regulatory cells
por: Reynolds, Ben C, et al.
Publicado: (2014)

Signal regulatory protein alpha (SIRPα) regulates the homeostasis of CD103(+)CD11b(+) DCs in the intestinal lamina propria
por: Scott, Charlotte L, et al.
Publicado: (2014)

Interleukin 17 inhibits progenitor cells in rheumatoid arthritis cartilage
por: Schminke, Boris, et al.
Publicado: (2015)

The site of allergen expression in hematopoietic cells determines the degree and quality of tolerance induced through molecular chimerism
por: Baranyi, Ulrike, et al.
Publicado: (2013)

IL‐12 and IL‐4 activate a CD39‐dependent intrinsic peripheral tolerance mechanism in CD8(+) T cells
por: Noble, Alistair, et al.
Publicado: (2016)

NFATc1 deficiency in T cells protects mice from experimental autoimmune encephalomyelitis
por: Reppert, Sarah, et al.
Publicado: (2015)

Non‐glycosidic compounds can stimulate both human and mouse iNKT cells
por: Jukes, John‐Paul, et al.
Publicado: (2016)

Human β‐defensin 3 increases the TLR9‐dependent response to bacterial DNA
por: McGlasson, Sarah L., et al.
Publicado: (2017)

The Dichotomous Responses Driven by β-Defensins
por: Shelley, Jennifer R., et al.
Publicado: (2020)

Effects of concomitant immunomodulators on the pharmacokinetics, efficacy and safety of adalimumab in patients with Crohn's disease or ulcerative colitis who had failed conventional therapy
por: Colombel, J.‐F., et al.
Publicado: (2016)

Peptide mimetics of immunoglobulin A (IgA) and FcαRI block IgA‐induced human neutrophil activation and migration
por: Heineke, Marieke H., et al.
Publicado: (2017)

Anti‐TNF treatment negatively regulates human CD4(+) T‐cell activation and maturation in vitro, but does not confer an anergic or suppressive phenotype
por: Povoleri, Giovanni A. M., et al.
Publicado: (2019)

Duplication and selection in the evolution of primate β-defensin genes
por: Semple, Colin AM, et al.
Publicado: (2003)

The soluble cytoplasmic tail of CD45 (ct‐CD45) in human plasma contributes to keep T cells in a quiescent state
por: Puck, Alexander, et al.
Publicado: (2016)

Human type 1 and type 2 conventional dendritic cells express indoleamine 2,3‐dioxygenase 1 with functional effects on T cell priming
por: Sittig, Simone P., et al.
Publicado: (2021)

Mesenteric lymph node stromal cell‐derived extracellular vesicles contribute to peripheral de novo induction of Foxp3(+) regulatory T cells
por: Pasztoi, Maria, et al.
Publicado: (2017)

Human dendritic cells activated with MV130 induce Th1, Th17 and IL‐10 responses via RIPK2 and MyD88 signalling pathways
por: Cirauqui, Cristina, et al.
Publicado: (2017)

FKBP51 modulates steroid sensitivity and NFκB signalling: A novel anti‐inflammatory drug target
por: Kästle, Marc, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_mlo1cf5pnmmvo49q6crmcvljef