Prostate cancer in BRCA2 germline mutation carriers is associated with poorer prognosis

BACKGROUND: The germline BRCA2 mutation is associated with increased prostate cancer (PrCa) risk. We have assessed survival in young PrCa cases with a germline mutation in BRCA2 and investigated loss of heterozygosity at BRCA2 in their tumours. METHODS: Two cohorts were compared: one was a group wit...

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Detalles Bibliográficos
Autores principales: Edwards, S M, Evans, D G R, Hope, Q, Norman, A R, Barbachano, Y, Bullock, S, Kote-Jarai, Z, Meitz, J, Falconer, A, Osin, P, Fisher, C, Guy, M, Jhavar, S G, Hall, A L, O'Brien, L T, Gehr-Swain, B N, Wilkinson, R A, Forrest, M S, Dearnaley, D P, Ardern-Jones, A T, Page, E C, Easton, D F, Eeles, R A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948551/
https://www.ncbi.nlm.nih.gov/pubmed/20736950
http://dx.doi.org/10.1038/sj.bjc.6605822

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