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Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1
Migraine is a common episodic neurological disorder, typically presenting with recurrent attacks of severe headache and autonomic dysfunction. Apart from rare monogenic subtypes, no genetic or molecular markers for migraine have been convincingly established. We identified the minor allele of rs1835...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948563/ https://www.ncbi.nlm.nih.gov/pubmed/20802479 http://dx.doi.org/10.1038/ng.652 |
| _version_ | 1782187478573121536 |
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| author | Anttila, Verneri Stefansson, Hreinn Kallela, Mikko Todt, Unda Terwindt, Gisela M Calafato, M Stella Nyholt, Dale R Dimas, Antigone S Freilinger, Tobias Müller-Myhsok, Bertram Artto, Ville Inouye, Michael Alakurtti, Kirsi Kaunisto, Mari A Hämäläinen, Eija de Vries, Boukje Stam, Anine H Weller, Claudia M Heinze, Axel Heinze-Kuhn, Katja Goebel, Ingrid Borck, Guntram Göbel, Hartmut Steinberg, Stacy Wolf, Christiane Björnsson, Asgeir Gudmundsson, Gretar Kirchmann, Malene Hauge, Anne Werge, Thomas Schoenen, Jean Eriksson, Johan G Hagen, Knut Stovner, Lars Wichmann, H-Erich Meitinger, Thomas Alexander, Michael Moebus, Susanne Schreiber, Stefan Aulchenko, Yurii S Breteler, Monique M B Uitterlinden, Andre G Hofman, Albert van Duijn, Cornelia M Tikka-Kleemola, Päivi Vepsäläinen, Salli Lucae, Susanne Tozzi, Federica Muglia, Pierandrea Barrett, Jeffrey Kaprio, Jaakko Färkkilä, Markus Peltonen, Leena Stefansson, Kari Zwart, John-Anker Ferrari, Michel D Olesen, Jes Daly, Mark Wessman, Maija van den Maagdenberg, Arn M J M Dichgans, Martin Kubisch, Christian Dermitzakis, Emmanouil T Frants, Rune R Palotie, Aarno |
| author_facet | Anttila, Verneri Stefansson, Hreinn Kallela, Mikko Todt, Unda Terwindt, Gisela M Calafato, M Stella Nyholt, Dale R Dimas, Antigone S Freilinger, Tobias Müller-Myhsok, Bertram Artto, Ville Inouye, Michael Alakurtti, Kirsi Kaunisto, Mari A Hämäläinen, Eija de Vries, Boukje Stam, Anine H Weller, Claudia M Heinze, Axel Heinze-Kuhn, Katja Goebel, Ingrid Borck, Guntram Göbel, Hartmut Steinberg, Stacy Wolf, Christiane Björnsson, Asgeir Gudmundsson, Gretar Kirchmann, Malene Hauge, Anne Werge, Thomas Schoenen, Jean Eriksson, Johan G Hagen, Knut Stovner, Lars Wichmann, H-Erich Meitinger, Thomas Alexander, Michael Moebus, Susanne Schreiber, Stefan Aulchenko, Yurii S Breteler, Monique M B Uitterlinden, Andre G Hofman, Albert van Duijn, Cornelia M Tikka-Kleemola, Päivi Vepsäläinen, Salli Lucae, Susanne Tozzi, Federica Muglia, Pierandrea Barrett, Jeffrey Kaprio, Jaakko Färkkilä, Markus Peltonen, Leena Stefansson, Kari Zwart, John-Anker Ferrari, Michel D Olesen, Jes Daly, Mark Wessman, Maija van den Maagdenberg, Arn M J M Dichgans, Martin Kubisch, Christian Dermitzakis, Emmanouil T Frants, Rune R Palotie, Aarno |
| author_sort | Anttila, Verneri |
| collection | PubMed |
| description | Migraine is a common episodic neurological disorder, typically presenting with recurrent attacks of severe headache and autonomic dysfunction. Apart from rare monogenic subtypes, no genetic or molecular markers for migraine have been convincingly established. We identified the minor allele of rs1835740 on chromosome 8q22.1 to be associated with migraine (p=5.12 × 10(−9), OR 1.23 [1.150-1.324]) in a genome-wide association study of 2,748 migraineurs from three European headache clinics and 10,747 population-matched controls. The association was replicated in 3,202 cases and 40,062 controls for an overall meta-analysis p-value of 1.60 × 10(−11) (OR 1.18 [1.127 – 1.244]). rs1835740 is located between the astrocyte elevated gene 1 (MTDH/AEG-1) and plasma glutamate carboxypeptidase (PGCP). In an expression quantitative trait study in lymphoblastoid cell lines transcript levels of the MTDH/AEG-1 were found to have a significant correlation to rs1835740. Our data establish rs1835740 as the first genetic risk factor for migraine. |
| format | Text |
| id | pubmed-2948563 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2010 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-29485632011-04-01 Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1 Anttila, Verneri Stefansson, Hreinn Kallela, Mikko Todt, Unda Terwindt, Gisela M Calafato, M Stella Nyholt, Dale R Dimas, Antigone S Freilinger, Tobias Müller-Myhsok, Bertram Artto, Ville Inouye, Michael Alakurtti, Kirsi Kaunisto, Mari A Hämäläinen, Eija de Vries, Boukje Stam, Anine H Weller, Claudia M Heinze, Axel Heinze-Kuhn, Katja Goebel, Ingrid Borck, Guntram Göbel, Hartmut Steinberg, Stacy Wolf, Christiane Björnsson, Asgeir Gudmundsson, Gretar Kirchmann, Malene Hauge, Anne Werge, Thomas Schoenen, Jean Eriksson, Johan G Hagen, Knut Stovner, Lars Wichmann, H-Erich Meitinger, Thomas Alexander, Michael Moebus, Susanne Schreiber, Stefan Aulchenko, Yurii S Breteler, Monique M B Uitterlinden, Andre G Hofman, Albert van Duijn, Cornelia M Tikka-Kleemola, Päivi Vepsäläinen, Salli Lucae, Susanne Tozzi, Federica Muglia, Pierandrea Barrett, Jeffrey Kaprio, Jaakko Färkkilä, Markus Peltonen, Leena Stefansson, Kari Zwart, John-Anker Ferrari, Michel D Olesen, Jes Daly, Mark Wessman, Maija van den Maagdenberg, Arn M J M Dichgans, Martin Kubisch, Christian Dermitzakis, Emmanouil T Frants, Rune R Palotie, Aarno Nat Genet Article Migraine is a common episodic neurological disorder, typically presenting with recurrent attacks of severe headache and autonomic dysfunction. Apart from rare monogenic subtypes, no genetic or molecular markers for migraine have been convincingly established. We identified the minor allele of rs1835740 on chromosome 8q22.1 to be associated with migraine (p=5.12 × 10(−9), OR 1.23 [1.150-1.324]) in a genome-wide association study of 2,748 migraineurs from three European headache clinics and 10,747 population-matched controls. The association was replicated in 3,202 cases and 40,062 controls for an overall meta-analysis p-value of 1.60 × 10(−11) (OR 1.18 [1.127 – 1.244]). rs1835740 is located between the astrocyte elevated gene 1 (MTDH/AEG-1) and plasma glutamate carboxypeptidase (PGCP). In an expression quantitative trait study in lymphoblastoid cell lines transcript levels of the MTDH/AEG-1 were found to have a significant correlation to rs1835740. Our data establish rs1835740 as the first genetic risk factor for migraine. 2010-08-29 2010-10 /pmc/articles/PMC2948563/ /pubmed/20802479 http://dx.doi.org/10.1038/ng.652 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Anttila, Verneri Stefansson, Hreinn Kallela, Mikko Todt, Unda Terwindt, Gisela M Calafato, M Stella Nyholt, Dale R Dimas, Antigone S Freilinger, Tobias Müller-Myhsok, Bertram Artto, Ville Inouye, Michael Alakurtti, Kirsi Kaunisto, Mari A Hämäläinen, Eija de Vries, Boukje Stam, Anine H Weller, Claudia M Heinze, Axel Heinze-Kuhn, Katja Goebel, Ingrid Borck, Guntram Göbel, Hartmut Steinberg, Stacy Wolf, Christiane Björnsson, Asgeir Gudmundsson, Gretar Kirchmann, Malene Hauge, Anne Werge, Thomas Schoenen, Jean Eriksson, Johan G Hagen, Knut Stovner, Lars Wichmann, H-Erich Meitinger, Thomas Alexander, Michael Moebus, Susanne Schreiber, Stefan Aulchenko, Yurii S Breteler, Monique M B Uitterlinden, Andre G Hofman, Albert van Duijn, Cornelia M Tikka-Kleemola, Päivi Vepsäläinen, Salli Lucae, Susanne Tozzi, Federica Muglia, Pierandrea Barrett, Jeffrey Kaprio, Jaakko Färkkilä, Markus Peltonen, Leena Stefansson, Kari Zwart, John-Anker Ferrari, Michel D Olesen, Jes Daly, Mark Wessman, Maija van den Maagdenberg, Arn M J M Dichgans, Martin Kubisch, Christian Dermitzakis, Emmanouil T Frants, Rune R Palotie, Aarno Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1 |
| title | Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1 |
| title_full | Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1 |
| title_fullStr | Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1 |
| title_full_unstemmed | Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1 |
| title_short | Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1 |
| title_sort | genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1 |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948563/ https://www.ncbi.nlm.nih.gov/pubmed/20802479 http://dx.doi.org/10.1038/ng.652 |
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