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Chromatin Modifying Agents in the In Vitro Production of Bovine Embryos

The low efficiency observed in cloning by nuclear transfer is related to an aberrant gene expression following errors in epigenetic reprogramming. Recent studies have focused on further understanding of the modifications that take place in the chromatin of embryos during the preimplantation period,...

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Autores principales: Monteiro, Fabio Morato, Oliveira, Clara Slade, Oliveira, Letícia Zoccolaro, Saraiva, Naiara Zoccal, Mercadante, Maria Eugênia Zerlotti, Lopes, Flavia Lombardi, Arnold, Daniel Robert, Garcia, Joaquim Mansano
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948908/
https://www.ncbi.nlm.nih.gov/pubmed/20936105
http://dx.doi.org/10.4061/2011/694817
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author Monteiro, Fabio Morato
Oliveira, Clara Slade
Oliveira, Letícia Zoccolaro
Saraiva, Naiara Zoccal
Mercadante, Maria Eugênia Zerlotti
Lopes, Flavia Lombardi
Arnold, Daniel Robert
Garcia, Joaquim Mansano
author_facet Monteiro, Fabio Morato
Oliveira, Clara Slade
Oliveira, Letícia Zoccolaro
Saraiva, Naiara Zoccal
Mercadante, Maria Eugênia Zerlotti
Lopes, Flavia Lombardi
Arnold, Daniel Robert
Garcia, Joaquim Mansano
author_sort Monteiro, Fabio Morato
collection PubMed
description The low efficiency observed in cloning by nuclear transfer is related to an aberrant gene expression following errors in epigenetic reprogramming. Recent studies have focused on further understanding of the modifications that take place in the chromatin of embryos during the preimplantation period, through the use of chromatin modifying agents. The goal of these studies is to identify the factors involved in nuclear reprogramming and to adjust in vitro manipulations in order to better mimic in vivo conditions. Therefore, proper knowledge of epigenetic reprogramming is necessary to prevent possible epigenetic errors and to improve efficiency and the use of in vitro fertilization and cloning technologies in cattle and other species.
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spelling pubmed-29489082010-10-08 Chromatin Modifying Agents in the In Vitro Production of Bovine Embryos Monteiro, Fabio Morato Oliveira, Clara Slade Oliveira, Letícia Zoccolaro Saraiva, Naiara Zoccal Mercadante, Maria Eugênia Zerlotti Lopes, Flavia Lombardi Arnold, Daniel Robert Garcia, Joaquim Mansano Vet Med Int Review Article The low efficiency observed in cloning by nuclear transfer is related to an aberrant gene expression following errors in epigenetic reprogramming. Recent studies have focused on further understanding of the modifications that take place in the chromatin of embryos during the preimplantation period, through the use of chromatin modifying agents. The goal of these studies is to identify the factors involved in nuclear reprogramming and to adjust in vitro manipulations in order to better mimic in vivo conditions. Therefore, proper knowledge of epigenetic reprogramming is necessary to prevent possible epigenetic errors and to improve efficiency and the use of in vitro fertilization and cloning technologies in cattle and other species. SAGE-Hindawi Access to Research 2010-09-29 /pmc/articles/PMC2948908/ /pubmed/20936105 http://dx.doi.org/10.4061/2011/694817 Text en Copyright © 2011 Fabio Morato Monteiro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Monteiro, Fabio Morato
Oliveira, Clara Slade
Oliveira, Letícia Zoccolaro
Saraiva, Naiara Zoccal
Mercadante, Maria Eugênia Zerlotti
Lopes, Flavia Lombardi
Arnold, Daniel Robert
Garcia, Joaquim Mansano
Chromatin Modifying Agents in the In Vitro Production of Bovine Embryos
title Chromatin Modifying Agents in the In Vitro Production of Bovine Embryos
title_full Chromatin Modifying Agents in the In Vitro Production of Bovine Embryos
title_fullStr Chromatin Modifying Agents in the In Vitro Production of Bovine Embryos
title_full_unstemmed Chromatin Modifying Agents in the In Vitro Production of Bovine Embryos
title_short Chromatin Modifying Agents in the In Vitro Production of Bovine Embryos
title_sort chromatin modifying agents in the in vitro production of bovine embryos
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948908/
https://www.ncbi.nlm.nih.gov/pubmed/20936105
http://dx.doi.org/10.4061/2011/694817
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