Toll-Like Receptor 3 in Liver Diseases

Toll-like receptor 3 (TLR3) is a member of the TLR family that can recognize double-stranded RNA (dsRNA), playing an important role in antiviral immunity. Recent studies have shown that TLR3 is also expressed on parenchymal and nonparenchymal cells in the liver as well as on several types of immune...

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Detalles Bibliográficos
Autores principales: Yin, Shi, Gao, Bin
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948910/
https://www.ncbi.nlm.nih.gov/pubmed/20936107
http://dx.doi.org/10.1155/2010/750904
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author Yin, Shi
Gao, Bin
author_facet Yin, Shi
Gao, Bin
author_sort Yin, Shi
collection PubMed
description Toll-like receptor 3 (TLR3) is a member of the TLR family that can recognize double-stranded RNA (dsRNA), playing an important role in antiviral immunity. Recent studies have shown that TLR3 is also expressed on parenchymal and nonparenchymal cells in the liver as well as on several types of immune cells. In this review, we summarize the role of TLR3 in liver injury, inflammation, regeneration, and liver fibrosis, and discuss the implication of TLR3 in the pathogenesis of human liver diseases including viral hepatitis and autoimmune liver disease.
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spelling pubmed-29489102010-10-08 Toll-Like Receptor 3 in Liver Diseases Yin, Shi Gao, Bin Gastroenterol Res Pract Review Article Toll-like receptor 3 (TLR3) is a member of the TLR family that can recognize double-stranded RNA (dsRNA), playing an important role in antiviral immunity. Recent studies have shown that TLR3 is also expressed on parenchymal and nonparenchymal cells in the liver as well as on several types of immune cells. In this review, we summarize the role of TLR3 in liver injury, inflammation, regeneration, and liver fibrosis, and discuss the implication of TLR3 in the pathogenesis of human liver diseases including viral hepatitis and autoimmune liver disease. Hindawi Publishing Corporation 2010 2010-09-23 /pmc/articles/PMC2948910/ /pubmed/20936107 http://dx.doi.org/10.1155/2010/750904 Text en Copyright © 2010 S. Yin and B. Gao. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Yin, Shi
Gao, Bin
Toll-Like Receptor 3 in Liver Diseases
title Toll-Like Receptor 3 in Liver Diseases
title_full Toll-Like Receptor 3 in Liver Diseases
title_fullStr Toll-Like Receptor 3 in Liver Diseases
title_full_unstemmed Toll-Like Receptor 3 in Liver Diseases
title_short Toll-Like Receptor 3 in Liver Diseases
title_sort toll-like receptor 3 in liver diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948910/
https://www.ncbi.nlm.nih.gov/pubmed/20936107
http://dx.doi.org/10.1155/2010/750904
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