BRCA1 Forms a Functional Complex with γ-H2AX as a Late Response to Genotoxic Stress

Following genotoxic stress, the histone H2AX becomes phosphorylated at serine 139 by the ATM/ATR family of kinases. The tumor suppressor BRCA1, also phosphorylated by ATM/ATR kinases, is one of several proteins that colocalize with phospho-H2AX (γ-H2AX) at sites of active DNA repair. Both the precis...

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Detalles Bibliográficos
Autores principales: Krum, Susan A., Dalugdugan, Esther de la Rosa, Miranda-Carboni, Gustavo A., Lane, Timothy F.
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948912/
https://www.ncbi.nlm.nih.gov/pubmed/20936109
http://dx.doi.org/10.4061/2010/801594

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