Chimeric design, synthesis, and biological assays of a new nonpeptide insulin-mimetic vanadium compound to inhibit protein tyrosine phosphatase 1B

Prior to its total synthesis, a new vanadium coordination compound, called TSAG0101, was computationally designed to inhibit the enzyme protein tyrosine phosphatase 1B (PTP1B). The PTP1B acts as a negative regulator of insulin signaling by blocking the active site where phosphate hydrolysis of the i...

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Detalles Bibliográficos
Autores principales: Scior, Thomas, Guevara-García, José Antonio, Melendez, FJ, Abdallah, Hassan H, Do, Quoc-Tuan, Bernard, Philippe
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2010
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948933/
https://www.ncbi.nlm.nih.gov/pubmed/20957214

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