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Genetic Determinants of Osteoporosis: Common Bases to Cardiovascular Diseases?

Osteoporosis is the most common and serious age-related skeletal disorder, characterized by a low bone mass and bone microarchitectural deterioration, with a consequent increase in bone fragility and susceptibility to spontaneous fractures, and it represents a major worldwide health care problem wit...

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Autores principales: Marini, Francesca, Brandi, Maria Luisa
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949079/
https://www.ncbi.nlm.nih.gov/pubmed/20948561
http://dx.doi.org/10.4061/2010/394579
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author Marini, Francesca
Brandi, Maria Luisa
author_facet Marini, Francesca
Brandi, Maria Luisa
author_sort Marini, Francesca
collection PubMed
description Osteoporosis is the most common and serious age-related skeletal disorder, characterized by a low bone mass and bone microarchitectural deterioration, with a consequent increase in bone fragility and susceptibility to spontaneous fractures, and it represents a major worldwide health care problem with important implications for health care costs, morbidity and mortality. Today is well accepted that osteoporosis is a multifactorial disorder caused by the interaction between environment and genes that singularly exert modest effects on bone mass and other aspects of bone strength and fracture risk. The individuation of genetic factors responsible for osteoporosis predisposition and development is fundamental for the disease prevention and for the setting of novel therapies, before fracture occurrence. In the last decades the interest of the Scientific Community has been concentrated in the understanding the genetic bases of this disease but with controversial and/or inconclusive results. This review tries to summarize data on the most representative osteoporosis candidate genes. Moreover, since recently osteoporosis and cardiovascular diseases have shown to share common physiopathological mechanisms, this review also provides information on the current understanding of osteoporosis and cardiovascular diseases common genetic bases.
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spelling pubmed-29490792010-10-14 Genetic Determinants of Osteoporosis: Common Bases to Cardiovascular Diseases? Marini, Francesca Brandi, Maria Luisa Int J Hypertens Research Article Osteoporosis is the most common and serious age-related skeletal disorder, characterized by a low bone mass and bone microarchitectural deterioration, with a consequent increase in bone fragility and susceptibility to spontaneous fractures, and it represents a major worldwide health care problem with important implications for health care costs, morbidity and mortality. Today is well accepted that osteoporosis is a multifactorial disorder caused by the interaction between environment and genes that singularly exert modest effects on bone mass and other aspects of bone strength and fracture risk. The individuation of genetic factors responsible for osteoporosis predisposition and development is fundamental for the disease prevention and for the setting of novel therapies, before fracture occurrence. In the last decades the interest of the Scientific Community has been concentrated in the understanding the genetic bases of this disease but with controversial and/or inconclusive results. This review tries to summarize data on the most representative osteoporosis candidate genes. Moreover, since recently osteoporosis and cardiovascular diseases have shown to share common physiopathological mechanisms, this review also provides information on the current understanding of osteoporosis and cardiovascular diseases common genetic bases. SAGE-Hindawi Access to Research 2010-03-25 /pmc/articles/PMC2949079/ /pubmed/20948561 http://dx.doi.org/10.4061/2010/394579 Text en Copyright © 2010 F. Marini and M. L. Brandi. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Marini, Francesca
Brandi, Maria Luisa
Genetic Determinants of Osteoporosis: Common Bases to Cardiovascular Diseases?
title Genetic Determinants of Osteoporosis: Common Bases to Cardiovascular Diseases?
title_full Genetic Determinants of Osteoporosis: Common Bases to Cardiovascular Diseases?
title_fullStr Genetic Determinants of Osteoporosis: Common Bases to Cardiovascular Diseases?
title_full_unstemmed Genetic Determinants of Osteoporosis: Common Bases to Cardiovascular Diseases?
title_short Genetic Determinants of Osteoporosis: Common Bases to Cardiovascular Diseases?
title_sort genetic determinants of osteoporosis: common bases to cardiovascular diseases?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949079/
https://www.ncbi.nlm.nih.gov/pubmed/20948561
http://dx.doi.org/10.4061/2010/394579
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