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Methods for Imaging Renin-Synthesizing, -Storing, and -Secreting Cells

Renin-producing cells have been the object of intense research efforts for the past fifty years within the field of hypertension. Two decades ago, research focused on the concept and characterization of the intrarenal renin-angiotensin system. Early morphological studies led to the concept of the ju...

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Autor principal: Casellas, Daniel
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949082/
https://www.ncbi.nlm.nih.gov/pubmed/20948562
http://dx.doi.org/10.4061/2010/298747
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author Casellas, Daniel
author_facet Casellas, Daniel
author_sort Casellas, Daniel
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description Renin-producing cells have been the object of intense research efforts for the past fifty years within the field of hypertension. Two decades ago, research focused on the concept and characterization of the intrarenal renin-angiotensin system. Early morphological studies led to the concept of the juxtaglomerular apparatus, a minute organ that links tubulovascular structures and function at the single nephron level. The kidney, thus, appears as a highly “topological organ” in which anatomy and function are intimately linked. This point is reflected by a concurrent and constant development of functional and structural approaches. After summarizing our current knowledge about renin cells and their distribution along the renal vascular tree, particularly along glomerular afferent arterioles, we reviewed a variety of imaging techniques that permit a fine characterization of renin synthesis, storage, and release at the single-arteriolar, -cell, or -granule level. Powerful tools such as multiphoton microscopy and transgenesis bear the promises of future developments of the field.
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spelling pubmed-29490822010-10-14 Methods for Imaging Renin-Synthesizing, -Storing, and -Secreting Cells Casellas, Daniel Int J Hypertens Review Article Renin-producing cells have been the object of intense research efforts for the past fifty years within the field of hypertension. Two decades ago, research focused on the concept and characterization of the intrarenal renin-angiotensin system. Early morphological studies led to the concept of the juxtaglomerular apparatus, a minute organ that links tubulovascular structures and function at the single nephron level. The kidney, thus, appears as a highly “topological organ” in which anatomy and function are intimately linked. This point is reflected by a concurrent and constant development of functional and structural approaches. After summarizing our current knowledge about renin cells and their distribution along the renal vascular tree, particularly along glomerular afferent arterioles, we reviewed a variety of imaging techniques that permit a fine characterization of renin synthesis, storage, and release at the single-arteriolar, -cell, or -granule level. Powerful tools such as multiphoton microscopy and transgenesis bear the promises of future developments of the field. SAGE-Hindawi Access to Research 2009-12-09 /pmc/articles/PMC2949082/ /pubmed/20948562 http://dx.doi.org/10.4061/2010/298747 Text en Copyright © 2010 Daniel Casellas. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Casellas, Daniel
Methods for Imaging Renin-Synthesizing, -Storing, and -Secreting Cells
title Methods for Imaging Renin-Synthesizing, -Storing, and -Secreting Cells
title_full Methods for Imaging Renin-Synthesizing, -Storing, and -Secreting Cells
title_fullStr Methods for Imaging Renin-Synthesizing, -Storing, and -Secreting Cells
title_full_unstemmed Methods for Imaging Renin-Synthesizing, -Storing, and -Secreting Cells
title_short Methods for Imaging Renin-Synthesizing, -Storing, and -Secreting Cells
title_sort methods for imaging renin-synthesizing, -storing, and -secreting cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949082/
https://www.ncbi.nlm.nih.gov/pubmed/20948562
http://dx.doi.org/10.4061/2010/298747
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