Generation of Human Antigen-Specific Monoclonal IgM Antibodies Using Vaccinated “Human Immune System” Mice

BACKGROUND: Passive transfer of antibodies not only provides immediate short-term protection against disease, but also can be exploited as a therapeutic tool. However, the ‘humanization’ of murine monoclonal antibodies (mAbs) is a time-consuming and expensive process that has the inherent drawback o...

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Detalles Bibliográficos
Autores principales: Becker, Pablo D., Legrand, Nicolas, van Geelen, Caroline M. M., Noerder, Miriam, Huntington, Nicholas D., Lim, Annick, Yasuda, Etsuko, Diehl, Sean A., Scheeren, Ferenc A., Ott, Michael, Weijer, Kees, Wedemeyer, Heiner, Di Santo, James P., Beaumont, Tim, Guzman, Carlos A., Spits, Hergen
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949385/
https://www.ncbi.nlm.nih.gov/pubmed/20957227
http://dx.doi.org/10.1371/journal.pone.0013137

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