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The culprit behind amyloid beta peptide related neurotoxicity in Alzheimer's disease: oligomer size or conformation?

Since the reformulation of the amyloid cascade hypothesis to focus on oligomeric aggregates of amyloid beta as the prime toxic species causing Alzheimer's disease, many researchers refocused on detecting a specific molecular assembly of defined size thatis the main trigger of Alzheimer's d...

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Detalles Bibliográficos
Autores principales: Broersen, Kerensa, Rousseau, Frederic, Schymkowitz, Joost
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949586/
https://www.ncbi.nlm.nih.gov/pubmed/20642866
http://dx.doi.org/10.1186/alzrt36