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Hemin inhibits NO production by IL-1β-stimulated human astrocytes through induction of heme oxygenase-1 and reduction of p38 MAPK activation

BACKGROUND: Heme oxygenase (HO)-1 has been shown to attenuate oxidative injury and reduce apoptosis. HO-1 can be induced by various stimuli released during cellular injury, such as heme. Deleterious free heme is degraded by HO-1 to carbon monoxide, iron and biliverdin, which have potent anti-oxidant...

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Detalles Bibliográficos
Autores principales:	Sheng, Wen S, Hu, Shuxian, Nettles, Adam R, Lokensgard, James R, Vercellotti, Gregory M, Rock, R Bryan
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949627/ https://www.ncbi.nlm.nih.gov/pubmed/20822529 http://dx.doi.org/10.1186/1742-2094-7-51

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