The Actin Gene Family: Function Follows Isoform

Although actin is often thought of as a single protein, in mammals it actually consists of six different isoforms encoded by separate genes. Each isoform is remarkably similar to every other isoform, with only slight variations in amino acid sequence. Nevertheless, recent work indicates that actin i...

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Detalles Bibliográficos
Autores principales: Perrin, Benjamin J, Ervasti, James M
Formato: Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2010
Materias:
Mini-Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949686/
https://www.ncbi.nlm.nih.gov/pubmed/20737541
http://dx.doi.org/10.1002/cm.20475
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author Perrin, Benjamin J
Ervasti, James M
author_facet Perrin, Benjamin J
Ervasti, James M
author_sort Perrin, Benjamin J
collection PubMed
description Although actin is often thought of as a single protein, in mammals it actually consists of six different isoforms encoded by separate genes. Each isoform is remarkably similar to every other isoform, with only slight variations in amino acid sequence. Nevertheless, recent work indicates that actin isoforms carry out unique cellular functions. Here, we review evidence drawn from localization studies, mouse models, and biochemical characterization to suggest a model for how in vivo mixing of actin isoforms may influence cytoskeletal function in cells. © 2010 Wiley-Liss, Inc.
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spelling pubmed-29496862011-02-15 The Actin Gene Family: Function Follows Isoform Perrin, Benjamin J Ervasti, James M Cytoskeleton (Hoboken) Mini-Review Although actin is often thought of as a single protein, in mammals it actually consists of six different isoforms encoded by separate genes. Each isoform is remarkably similar to every other isoform, with only slight variations in amino acid sequence. Nevertheless, recent work indicates that actin isoforms carry out unique cellular functions. Here, we review evidence drawn from localization studies, mouse models, and biochemical characterization to suggest a model for how in vivo mixing of actin isoforms may influence cytoskeletal function in cells. © 2010 Wiley-Liss, Inc. John Wiley & Sons, Inc. 2010-10 2010-08-24 /pmc/articles/PMC2949686/ /pubmed/20737541 http://dx.doi.org/10.1002/cm.20475 Text en Copyright © 2010 Wiley-Liss, Inc., A Wiley Company http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Mini-Review
Perrin, Benjamin J
Ervasti, James M
The Actin Gene Family: Function Follows Isoform
title The Actin Gene Family: Function Follows Isoform
title_full The Actin Gene Family: Function Follows Isoform
title_fullStr The Actin Gene Family: Function Follows Isoform
title_full_unstemmed The Actin Gene Family: Function Follows Isoform
title_short The Actin Gene Family: Function Follows Isoform
title_sort actin gene family: function follows isoform
topic Mini-Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949686/
https://www.ncbi.nlm.nih.gov/pubmed/20737541
http://dx.doi.org/10.1002/cm.20475
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