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The effects of a DTNBP1 gene variant on attention networks: an fMRI study

BACKGROUND: Attention deficits belong to the main cognitive symptoms of schizophrenia and come along with altered neural activity in previously described cerebral networks. Given the high heritability of schizophrenia the question arises if impaired function of these networks is modulated by suscept...

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Autores principales: Thimm, Markus, Krug, Axel, Kellermann, Thilo, Markov, Valentin, Krach, Sören, Jansen, Andreas, Zerres, Klaus, Eggermann, Thomas, Stöcker, Tony, Shah, N Jon, Nöthen, Markus M, Rietschel, Marcella, Kircher, Tilo
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949706/
https://www.ncbi.nlm.nih.gov/pubmed/20846375
http://dx.doi.org/10.1186/1744-9081-6-54
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author Thimm, Markus
Krug, Axel
Kellermann, Thilo
Markov, Valentin
Krach, Sören
Jansen, Andreas
Zerres, Klaus
Eggermann, Thomas
Stöcker, Tony
Shah, N Jon
Nöthen, Markus M
Rietschel, Marcella
Kircher, Tilo
author_facet Thimm, Markus
Krug, Axel
Kellermann, Thilo
Markov, Valentin
Krach, Sören
Jansen, Andreas
Zerres, Klaus
Eggermann, Thomas
Stöcker, Tony
Shah, N Jon
Nöthen, Markus M
Rietschel, Marcella
Kircher, Tilo
author_sort Thimm, Markus
collection PubMed
description BACKGROUND: Attention deficits belong to the main cognitive symptoms of schizophrenia and come along with altered neural activity in previously described cerebral networks. Given the high heritability of schizophrenia the question arises if impaired function of these networks is modulated by susceptibility genes and detectable in healthy risk allele carriers. METHODS: The present event-related fMRI study investigated the effect of the single nucleotide polymorphism (SNP) rs1018381 of the DTNBP1 (dystrobrevin-binding protein 1) gene on brain activity in 80 subjects while performing the attention network test (ANT). In this reaction time task three domains of attention are probed simultaneously: alerting, orienting and executive control of attention. RESULTS: Risk allele carriers showed impaired performance in the executive control condition associated with reduced neural activity in the left superior frontal gyrus [Brodmann area (BA) 9]. Risk allele carriers did not show alterations in the alerting and orienting networks. CONCLUSIONS: BA 9 is a key region of schizophrenia pathology and belongs to a network that has been shown previously to be involved in impaired executive control mechanisms in schizophrenia. Our results identified the impact of DTNBP1 on the development of a specific attention deficit via modulation of a left prefrontal network.
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spelling pubmed-29497062010-10-06 The effects of a DTNBP1 gene variant on attention networks: an fMRI study Thimm, Markus Krug, Axel Kellermann, Thilo Markov, Valentin Krach, Sören Jansen, Andreas Zerres, Klaus Eggermann, Thomas Stöcker, Tony Shah, N Jon Nöthen, Markus M Rietschel, Marcella Kircher, Tilo Behav Brain Funct Research BACKGROUND: Attention deficits belong to the main cognitive symptoms of schizophrenia and come along with altered neural activity in previously described cerebral networks. Given the high heritability of schizophrenia the question arises if impaired function of these networks is modulated by susceptibility genes and detectable in healthy risk allele carriers. METHODS: The present event-related fMRI study investigated the effect of the single nucleotide polymorphism (SNP) rs1018381 of the DTNBP1 (dystrobrevin-binding protein 1) gene on brain activity in 80 subjects while performing the attention network test (ANT). In this reaction time task three domains of attention are probed simultaneously: alerting, orienting and executive control of attention. RESULTS: Risk allele carriers showed impaired performance in the executive control condition associated with reduced neural activity in the left superior frontal gyrus [Brodmann area (BA) 9]. Risk allele carriers did not show alterations in the alerting and orienting networks. CONCLUSIONS: BA 9 is a key region of schizophrenia pathology and belongs to a network that has been shown previously to be involved in impaired executive control mechanisms in schizophrenia. Our results identified the impact of DTNBP1 on the development of a specific attention deficit via modulation of a left prefrontal network. BioMed Central 2010-09-16 /pmc/articles/PMC2949706/ /pubmed/20846375 http://dx.doi.org/10.1186/1744-9081-6-54 Text en Copyright ©2010 Thimm et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Thimm, Markus
Krug, Axel
Kellermann, Thilo
Markov, Valentin
Krach, Sören
Jansen, Andreas
Zerres, Klaus
Eggermann, Thomas
Stöcker, Tony
Shah, N Jon
Nöthen, Markus M
Rietschel, Marcella
Kircher, Tilo
The effects of a DTNBP1 gene variant on attention networks: an fMRI study
title The effects of a DTNBP1 gene variant on attention networks: an fMRI study
title_full The effects of a DTNBP1 gene variant on attention networks: an fMRI study
title_fullStr The effects of a DTNBP1 gene variant on attention networks: an fMRI study
title_full_unstemmed The effects of a DTNBP1 gene variant on attention networks: an fMRI study
title_short The effects of a DTNBP1 gene variant on attention networks: an fMRI study
title_sort effects of a dtnbp1 gene variant on attention networks: an fmri study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949706/
https://www.ncbi.nlm.nih.gov/pubmed/20846375
http://dx.doi.org/10.1186/1744-9081-6-54
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