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The effects of a DTNBP1 gene variant on attention networks: an fMRI study
BACKGROUND: Attention deficits belong to the main cognitive symptoms of schizophrenia and come along with altered neural activity in previously described cerebral networks. Given the high heritability of schizophrenia the question arises if impaired function of these networks is modulated by suscept...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949706/ https://www.ncbi.nlm.nih.gov/pubmed/20846375 http://dx.doi.org/10.1186/1744-9081-6-54 |
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author | Thimm, Markus Krug, Axel Kellermann, Thilo Markov, Valentin Krach, Sören Jansen, Andreas Zerres, Klaus Eggermann, Thomas Stöcker, Tony Shah, N Jon Nöthen, Markus M Rietschel, Marcella Kircher, Tilo |
author_facet | Thimm, Markus Krug, Axel Kellermann, Thilo Markov, Valentin Krach, Sören Jansen, Andreas Zerres, Klaus Eggermann, Thomas Stöcker, Tony Shah, N Jon Nöthen, Markus M Rietschel, Marcella Kircher, Tilo |
author_sort | Thimm, Markus |
collection | PubMed |
description | BACKGROUND: Attention deficits belong to the main cognitive symptoms of schizophrenia and come along with altered neural activity in previously described cerebral networks. Given the high heritability of schizophrenia the question arises if impaired function of these networks is modulated by susceptibility genes and detectable in healthy risk allele carriers. METHODS: The present event-related fMRI study investigated the effect of the single nucleotide polymorphism (SNP) rs1018381 of the DTNBP1 (dystrobrevin-binding protein 1) gene on brain activity in 80 subjects while performing the attention network test (ANT). In this reaction time task three domains of attention are probed simultaneously: alerting, orienting and executive control of attention. RESULTS: Risk allele carriers showed impaired performance in the executive control condition associated with reduced neural activity in the left superior frontal gyrus [Brodmann area (BA) 9]. Risk allele carriers did not show alterations in the alerting and orienting networks. CONCLUSIONS: BA 9 is a key region of schizophrenia pathology and belongs to a network that has been shown previously to be involved in impaired executive control mechanisms in schizophrenia. Our results identified the impact of DTNBP1 on the development of a specific attention deficit via modulation of a left prefrontal network. |
format | Text |
id | pubmed-2949706 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-29497062010-10-06 The effects of a DTNBP1 gene variant on attention networks: an fMRI study Thimm, Markus Krug, Axel Kellermann, Thilo Markov, Valentin Krach, Sören Jansen, Andreas Zerres, Klaus Eggermann, Thomas Stöcker, Tony Shah, N Jon Nöthen, Markus M Rietschel, Marcella Kircher, Tilo Behav Brain Funct Research BACKGROUND: Attention deficits belong to the main cognitive symptoms of schizophrenia and come along with altered neural activity in previously described cerebral networks. Given the high heritability of schizophrenia the question arises if impaired function of these networks is modulated by susceptibility genes and detectable in healthy risk allele carriers. METHODS: The present event-related fMRI study investigated the effect of the single nucleotide polymorphism (SNP) rs1018381 of the DTNBP1 (dystrobrevin-binding protein 1) gene on brain activity in 80 subjects while performing the attention network test (ANT). In this reaction time task three domains of attention are probed simultaneously: alerting, orienting and executive control of attention. RESULTS: Risk allele carriers showed impaired performance in the executive control condition associated with reduced neural activity in the left superior frontal gyrus [Brodmann area (BA) 9]. Risk allele carriers did not show alterations in the alerting and orienting networks. CONCLUSIONS: BA 9 is a key region of schizophrenia pathology and belongs to a network that has been shown previously to be involved in impaired executive control mechanisms in schizophrenia. Our results identified the impact of DTNBP1 on the development of a specific attention deficit via modulation of a left prefrontal network. BioMed Central 2010-09-16 /pmc/articles/PMC2949706/ /pubmed/20846375 http://dx.doi.org/10.1186/1744-9081-6-54 Text en Copyright ©2010 Thimm et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Thimm, Markus Krug, Axel Kellermann, Thilo Markov, Valentin Krach, Sören Jansen, Andreas Zerres, Klaus Eggermann, Thomas Stöcker, Tony Shah, N Jon Nöthen, Markus M Rietschel, Marcella Kircher, Tilo The effects of a DTNBP1 gene variant on attention networks: an fMRI study |
title | The effects of a DTNBP1 gene variant on attention networks: an fMRI study |
title_full | The effects of a DTNBP1 gene variant on attention networks: an fMRI study |
title_fullStr | The effects of a DTNBP1 gene variant on attention networks: an fMRI study |
title_full_unstemmed | The effects of a DTNBP1 gene variant on attention networks: an fMRI study |
title_short | The effects of a DTNBP1 gene variant on attention networks: an fMRI study |
title_sort | effects of a dtnbp1 gene variant on attention networks: an fmri study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949706/ https://www.ncbi.nlm.nih.gov/pubmed/20846375 http://dx.doi.org/10.1186/1744-9081-6-54 |
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