Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase

BACKGROUND: Ceramide is an important second messenger that has diverse cellular and biological effect. It is a specific and potent inducer of apoptosis and suppressor of cell growth. In leukemia, chemoresistance generally developed due to deregulated ceramide metabolism. In combinatorial treatment s...

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Detalles Bibliográficos
Autores principales: Mondal, Susmita, Mandal, Chandan, Sangwan, Rajender, Chandra, Sarmila, Mandal, Chitra
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949798/
https://www.ncbi.nlm.nih.gov/pubmed/20836852
http://dx.doi.org/10.1186/1476-4598-9-239

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949798/
https://www.ncbi.nlm.nih.gov/pubmed/20836852
http://dx.doi.org/10.1186/1476-4598-9-239

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