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Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase
BACKGROUND: Ceramide is an important second messenger that has diverse cellular and biological effect. It is a specific and potent inducer of apoptosis and suppressor of cell growth. In leukemia, chemoresistance generally developed due to deregulated ceramide metabolism. In combinatorial treatment s...
Autores principales: | Mondal, Susmita, Mandal, Chandan, Sangwan, Rajender, Chandra, Sarmila, Mandal, Chitra |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949798/ https://www.ncbi.nlm.nih.gov/pubmed/20836852 http://dx.doi.org/10.1186/1476-4598-9-239 |
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