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Dietary iron intake in the first 4 months of infancy and the development of type 1 diabetes: a pilot study
AIMS: To investigate the impact of iron intake on the development of type 1 diabetes (T1DM). METHODS: Case-control study with self-administered questionnaire among families of children with T1DM who were less than 10 years old at the time of the survey and developed diabetes between age 1 and 6 year...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949812/ https://www.ncbi.nlm.nih.gov/pubmed/20854668 http://dx.doi.org/10.1186/1758-5996-2-58 |
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author | Ashraf, Ambika P Eason, Nancy B Kabagambe, Edmond K Haritha, Josna Meleth, Sreelatha McCormick, Kenneth L |
author_facet | Ashraf, Ambika P Eason, Nancy B Kabagambe, Edmond K Haritha, Josna Meleth, Sreelatha McCormick, Kenneth L |
author_sort | Ashraf, Ambika P |
collection | PubMed |
description | AIMS: To investigate the impact of iron intake on the development of type 1 diabetes (T1DM). METHODS: Case-control study with self-administered questionnaire among families of children with T1DM who were less than 10 years old at the time of the survey and developed diabetes between age 1 and 6 years. Data on the types of infant feeding in the first 4 months of life was collected from parents of children with T1DM (n = 128) and controls (n = 67) <10 years old. Because some cases had sibling controls, we used conditional logistic regression models to analyze the data in two ways. First we performed a case-control analysis of all 128 cases and 67 controls. Next, we performed a case-control analysis restricted to cases (n = 59) that had a sibling without diabetes (n = 59). Total iron intake was modeled as one standard deviation (SD) increase in iron intake. The SD for iron intake was 540 mg in the total sample and 539 mg in the restricted sample as defined above. RESULTS: The median (min, max) total iron intake in the first 4 months of life was 1159 (50, 2399) mg in T1DM cases and 466 (50, 1224) mg among controls (P < 0.001). For each one standard deviation increase in iron intake, the odds ratio (95% confidence interval) for type 1 diabetes was 2.01 (1.183, 3.41) among all participants (128 cases and 67 controls) while it was 2.26 (1.27, 4.03) in a restricted sample of T1 D cases with a control sibling (59 cases and 59 controls) in models adjusted for birth weight, age at the time of the survey, and birth order. CONCLUSION: In this pilot study, high iron intake in the first 4 months of infancy is associated with T1DM. Whether iron intake is causal or a marker of another risk factor warrants further investigation. |
format | Text |
id | pubmed-2949812 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-29498122010-10-06 Dietary iron intake in the first 4 months of infancy and the development of type 1 diabetes: a pilot study Ashraf, Ambika P Eason, Nancy B Kabagambe, Edmond K Haritha, Josna Meleth, Sreelatha McCormick, Kenneth L Diabetol Metab Syndr Research AIMS: To investigate the impact of iron intake on the development of type 1 diabetes (T1DM). METHODS: Case-control study with self-administered questionnaire among families of children with T1DM who were less than 10 years old at the time of the survey and developed diabetes between age 1 and 6 years. Data on the types of infant feeding in the first 4 months of life was collected from parents of children with T1DM (n = 128) and controls (n = 67) <10 years old. Because some cases had sibling controls, we used conditional logistic regression models to analyze the data in two ways. First we performed a case-control analysis of all 128 cases and 67 controls. Next, we performed a case-control analysis restricted to cases (n = 59) that had a sibling without diabetes (n = 59). Total iron intake was modeled as one standard deviation (SD) increase in iron intake. The SD for iron intake was 540 mg in the total sample and 539 mg in the restricted sample as defined above. RESULTS: The median (min, max) total iron intake in the first 4 months of life was 1159 (50, 2399) mg in T1DM cases and 466 (50, 1224) mg among controls (P < 0.001). For each one standard deviation increase in iron intake, the odds ratio (95% confidence interval) for type 1 diabetes was 2.01 (1.183, 3.41) among all participants (128 cases and 67 controls) while it was 2.26 (1.27, 4.03) in a restricted sample of T1 D cases with a control sibling (59 cases and 59 controls) in models adjusted for birth weight, age at the time of the survey, and birth order. CONCLUSION: In this pilot study, high iron intake in the first 4 months of infancy is associated with T1DM. Whether iron intake is causal or a marker of another risk factor warrants further investigation. BioMed Central 2010-09-20 /pmc/articles/PMC2949812/ /pubmed/20854668 http://dx.doi.org/10.1186/1758-5996-2-58 Text en Copyright ©2010 Ashraf et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Ashraf, Ambika P Eason, Nancy B Kabagambe, Edmond K Haritha, Josna Meleth, Sreelatha McCormick, Kenneth L Dietary iron intake in the first 4 months of infancy and the development of type 1 diabetes: a pilot study |
title | Dietary iron intake in the first 4 months of infancy and the development of type 1 diabetes: a pilot study |
title_full | Dietary iron intake in the first 4 months of infancy and the development of type 1 diabetes: a pilot study |
title_fullStr | Dietary iron intake in the first 4 months of infancy and the development of type 1 diabetes: a pilot study |
title_full_unstemmed | Dietary iron intake in the first 4 months of infancy and the development of type 1 diabetes: a pilot study |
title_short | Dietary iron intake in the first 4 months of infancy and the development of type 1 diabetes: a pilot study |
title_sort | dietary iron intake in the first 4 months of infancy and the development of type 1 diabetes: a pilot study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949812/ https://www.ncbi.nlm.nih.gov/pubmed/20854668 http://dx.doi.org/10.1186/1758-5996-2-58 |
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