Cargando…

Dietary iron intake in the first 4 months of infancy and the development of type 1 diabetes: a pilot study

AIMS: To investigate the impact of iron intake on the development of type 1 diabetes (T1DM). METHODS: Case-control study with self-administered questionnaire among families of children with T1DM who were less than 10 years old at the time of the survey and developed diabetes between age 1 and 6 year...

Descripción completa

Detalles Bibliográficos
Autores principales: Ashraf, Ambika P, Eason, Nancy B, Kabagambe, Edmond K, Haritha, Josna, Meleth, Sreelatha, McCormick, Kenneth L
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949812/
https://www.ncbi.nlm.nih.gov/pubmed/20854668
http://dx.doi.org/10.1186/1758-5996-2-58
_version_ 1782187585821474816
author Ashraf, Ambika P
Eason, Nancy B
Kabagambe, Edmond K
Haritha, Josna
Meleth, Sreelatha
McCormick, Kenneth L
author_facet Ashraf, Ambika P
Eason, Nancy B
Kabagambe, Edmond K
Haritha, Josna
Meleth, Sreelatha
McCormick, Kenneth L
author_sort Ashraf, Ambika P
collection PubMed
description AIMS: To investigate the impact of iron intake on the development of type 1 diabetes (T1DM). METHODS: Case-control study with self-administered questionnaire among families of children with T1DM who were less than 10 years old at the time of the survey and developed diabetes between age 1 and 6 years. Data on the types of infant feeding in the first 4 months of life was collected from parents of children with T1DM (n = 128) and controls (n = 67) <10 years old. Because some cases had sibling controls, we used conditional logistic regression models to analyze the data in two ways. First we performed a case-control analysis of all 128 cases and 67 controls. Next, we performed a case-control analysis restricted to cases (n = 59) that had a sibling without diabetes (n = 59). Total iron intake was modeled as one standard deviation (SD) increase in iron intake. The SD for iron intake was 540 mg in the total sample and 539 mg in the restricted sample as defined above. RESULTS: The median (min, max) total iron intake in the first 4 months of life was 1159 (50, 2399) mg in T1DM cases and 466 (50, 1224) mg among controls (P < 0.001). For each one standard deviation increase in iron intake, the odds ratio (95% confidence interval) for type 1 diabetes was 2.01 (1.183, 3.41) among all participants (128 cases and 67 controls) while it was 2.26 (1.27, 4.03) in a restricted sample of T1 D cases with a control sibling (59 cases and 59 controls) in models adjusted for birth weight, age at the time of the survey, and birth order. CONCLUSION: In this pilot study, high iron intake in the first 4 months of infancy is associated with T1DM. Whether iron intake is causal or a marker of another risk factor warrants further investigation.
format Text
id pubmed-2949812
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-29498122010-10-06 Dietary iron intake in the first 4 months of infancy and the development of type 1 diabetes: a pilot study Ashraf, Ambika P Eason, Nancy B Kabagambe, Edmond K Haritha, Josna Meleth, Sreelatha McCormick, Kenneth L Diabetol Metab Syndr Research AIMS: To investigate the impact of iron intake on the development of type 1 diabetes (T1DM). METHODS: Case-control study with self-administered questionnaire among families of children with T1DM who were less than 10 years old at the time of the survey and developed diabetes between age 1 and 6 years. Data on the types of infant feeding in the first 4 months of life was collected from parents of children with T1DM (n = 128) and controls (n = 67) <10 years old. Because some cases had sibling controls, we used conditional logistic regression models to analyze the data in two ways. First we performed a case-control analysis of all 128 cases and 67 controls. Next, we performed a case-control analysis restricted to cases (n = 59) that had a sibling without diabetes (n = 59). Total iron intake was modeled as one standard deviation (SD) increase in iron intake. The SD for iron intake was 540 mg in the total sample and 539 mg in the restricted sample as defined above. RESULTS: The median (min, max) total iron intake in the first 4 months of life was 1159 (50, 2399) mg in T1DM cases and 466 (50, 1224) mg among controls (P < 0.001). For each one standard deviation increase in iron intake, the odds ratio (95% confidence interval) for type 1 diabetes was 2.01 (1.183, 3.41) among all participants (128 cases and 67 controls) while it was 2.26 (1.27, 4.03) in a restricted sample of T1 D cases with a control sibling (59 cases and 59 controls) in models adjusted for birth weight, age at the time of the survey, and birth order. CONCLUSION: In this pilot study, high iron intake in the first 4 months of infancy is associated with T1DM. Whether iron intake is causal or a marker of another risk factor warrants further investigation. BioMed Central 2010-09-20 /pmc/articles/PMC2949812/ /pubmed/20854668 http://dx.doi.org/10.1186/1758-5996-2-58 Text en Copyright ©2010 Ashraf et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Ashraf, Ambika P
Eason, Nancy B
Kabagambe, Edmond K
Haritha, Josna
Meleth, Sreelatha
McCormick, Kenneth L
Dietary iron intake in the first 4 months of infancy and the development of type 1 diabetes: a pilot study
title Dietary iron intake in the first 4 months of infancy and the development of type 1 diabetes: a pilot study
title_full Dietary iron intake in the first 4 months of infancy and the development of type 1 diabetes: a pilot study
title_fullStr Dietary iron intake in the first 4 months of infancy and the development of type 1 diabetes: a pilot study
title_full_unstemmed Dietary iron intake in the first 4 months of infancy and the development of type 1 diabetes: a pilot study
title_short Dietary iron intake in the first 4 months of infancy and the development of type 1 diabetes: a pilot study
title_sort dietary iron intake in the first 4 months of infancy and the development of type 1 diabetes: a pilot study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949812/
https://www.ncbi.nlm.nih.gov/pubmed/20854668
http://dx.doi.org/10.1186/1758-5996-2-58
work_keys_str_mv AT ashrafambikap dietaryironintakeinthefirst4monthsofinfancyandthedevelopmentoftype1diabetesapilotstudy
AT easonnancyb dietaryironintakeinthefirst4monthsofinfancyandthedevelopmentoftype1diabetesapilotstudy
AT kabagambeedmondk dietaryironintakeinthefirst4monthsofinfancyandthedevelopmentoftype1diabetesapilotstudy
AT harithajosna dietaryironintakeinthefirst4monthsofinfancyandthedevelopmentoftype1diabetesapilotstudy
AT melethsreelatha dietaryironintakeinthefirst4monthsofinfancyandthedevelopmentoftype1diabetesapilotstudy
AT mccormickkennethl dietaryironintakeinthefirst4monthsofinfancyandthedevelopmentoftype1diabetesapilotstudy