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Decreased health-related quality of life in disease-free survivors of differentiated thyroid cancer in Korea

BACKGROUND: Concern regarding the health-related quality of life (HRQOL) of long-term survivors of thyroid cancer has risen due to the rapid increase in the incidence of thyroid cancer, which generally has an excellent prognosis. The aim of this study was to evaluate the status of HRQOL in disease-f...

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Autores principales: Lee, Ji In, Kim, Soo Hyun, Tan, Alice H, Kim, Hee Kyung, Jang, Hye Won, Hur, Kyu Yeon, Kim, Jae Hyeon, Kim, Kwang-Won, Chung, Jae Hoon, Kim, Sun Wook
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949818/
https://www.ncbi.nlm.nih.gov/pubmed/20840792
http://dx.doi.org/10.1186/1477-7525-8-101
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author Lee, Ji In
Kim, Soo Hyun
Tan, Alice H
Kim, Hee Kyung
Jang, Hye Won
Hur, Kyu Yeon
Kim, Jae Hyeon
Kim, Kwang-Won
Chung, Jae Hoon
Kim, Sun Wook
author_facet Lee, Ji In
Kim, Soo Hyun
Tan, Alice H
Kim, Hee Kyung
Jang, Hye Won
Hur, Kyu Yeon
Kim, Jae Hyeon
Kim, Kwang-Won
Chung, Jae Hoon
Kim, Sun Wook
author_sort Lee, Ji In
collection PubMed
description BACKGROUND: Concern regarding the health-related quality of life (HRQOL) of long-term survivors of thyroid cancer has risen due to the rapid increase in the incidence of thyroid cancer, which generally has an excellent prognosis. The aim of this study was to evaluate the status of HRQOL in disease-free survivors of differentiated thyroid carcinoma (DTC) and to evaluate the important determinants of HRQOL. METHODS: This was a cross-sectional study in which we interviewed consecutive disease-free survivors of DTC. Three different validated questionnaires ("EORTC QLQ-C30" for various functional domains, the "brief fatigue inventory (BFI)" and the "hospital anxiety and depression scale" (HADS)) were used. Data from a large, population based survey of 1,000 people were used as a control. RESULTS: The response rate for the questionnaires was 78.9% (316/401). Disease-free survivors of DTC showed a decreased HRQOL in all five functional domains (physical, role, cognitive, emotional, and social) on the EORTC QLQ-C30 compared with controls (P < 0.01). BFI and HADS-anxiety scores also showed greater distress in disease-free survivors of DTC than in controls (P < 0.05). A multiple regression analysis for the determinants of HRQOL showed that the HADS-anxiety, HADS-depression, and BFI scores were the most significant components of decreased HRQOL. CONCLUSIONS: Although disease-free survivors of DTC are expected to have disease-specific survival comparable to the general population, they experience a significantly decreased HRQOL. Anxiety, depression, and fatigue were the major determinants of the decreased HRQOL. Supportive psychological care should be integrated into the management of long-term survivors of DTC.
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spelling pubmed-29498182010-10-06 Decreased health-related quality of life in disease-free survivors of differentiated thyroid cancer in Korea Lee, Ji In Kim, Soo Hyun Tan, Alice H Kim, Hee Kyung Jang, Hye Won Hur, Kyu Yeon Kim, Jae Hyeon Kim, Kwang-Won Chung, Jae Hoon Kim, Sun Wook Health Qual Life Outcomes Research BACKGROUND: Concern regarding the health-related quality of life (HRQOL) of long-term survivors of thyroid cancer has risen due to the rapid increase in the incidence of thyroid cancer, which generally has an excellent prognosis. The aim of this study was to evaluate the status of HRQOL in disease-free survivors of differentiated thyroid carcinoma (DTC) and to evaluate the important determinants of HRQOL. METHODS: This was a cross-sectional study in which we interviewed consecutive disease-free survivors of DTC. Three different validated questionnaires ("EORTC QLQ-C30" for various functional domains, the "brief fatigue inventory (BFI)" and the "hospital anxiety and depression scale" (HADS)) were used. Data from a large, population based survey of 1,000 people were used as a control. RESULTS: The response rate for the questionnaires was 78.9% (316/401). Disease-free survivors of DTC showed a decreased HRQOL in all five functional domains (physical, role, cognitive, emotional, and social) on the EORTC QLQ-C30 compared with controls (P < 0.01). BFI and HADS-anxiety scores also showed greater distress in disease-free survivors of DTC than in controls (P < 0.05). A multiple regression analysis for the determinants of HRQOL showed that the HADS-anxiety, HADS-depression, and BFI scores were the most significant components of decreased HRQOL. CONCLUSIONS: Although disease-free survivors of DTC are expected to have disease-specific survival comparable to the general population, they experience a significantly decreased HRQOL. Anxiety, depression, and fatigue were the major determinants of the decreased HRQOL. Supportive psychological care should be integrated into the management of long-term survivors of DTC. BioMed Central 2010-09-15 /pmc/articles/PMC2949818/ /pubmed/20840792 http://dx.doi.org/10.1186/1477-7525-8-101 Text en Copyright ©2010 Lee et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Lee, Ji In
Kim, Soo Hyun
Tan, Alice H
Kim, Hee Kyung
Jang, Hye Won
Hur, Kyu Yeon
Kim, Jae Hyeon
Kim, Kwang-Won
Chung, Jae Hoon
Kim, Sun Wook
Decreased health-related quality of life in disease-free survivors of differentiated thyroid cancer in Korea
title Decreased health-related quality of life in disease-free survivors of differentiated thyroid cancer in Korea
title_full Decreased health-related quality of life in disease-free survivors of differentiated thyroid cancer in Korea
title_fullStr Decreased health-related quality of life in disease-free survivors of differentiated thyroid cancer in Korea
title_full_unstemmed Decreased health-related quality of life in disease-free survivors of differentiated thyroid cancer in Korea
title_short Decreased health-related quality of life in disease-free survivors of differentiated thyroid cancer in Korea
title_sort decreased health-related quality of life in disease-free survivors of differentiated thyroid cancer in korea
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949818/
https://www.ncbi.nlm.nih.gov/pubmed/20840792
http://dx.doi.org/10.1186/1477-7525-8-101
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