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Reduction of lung metastasis, cell invasion, and adhesion in mouse melanoma by statin-induced blockade of the Rho/Rho-associated coiled-coil-containing protein kinase pathway
BACKGROUND: Melanomas are highly malignant and have high metastatic potential; hence, there is a need for new therapeutic strategies to prevent cell metastasis. In the present study, we investigated whether statins inhibit tumor cell migration, invasion, adhesion, and metastasis in the B16BL6 mouse...
Autores principales: | Kidera, Yasuhiro, Tsubaki, Masanobu, Yamazoe, Yuzuru, Shoji, Kaori, Nakamura, Haruyuki, Ogaki, Mitsuhiko, Satou, Takao, Itoh, Tatsuki, Isozaki, Misako, Kaneko, Junichi, Tanimori, Yoshihiro, Yanae, Masashi, Nishida, Shozo |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949822/ https://www.ncbi.nlm.nih.gov/pubmed/20843370 http://dx.doi.org/10.1186/1756-9966-29-127 |
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