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Increased amyloidogenic processing of transgenic human APP in X11-like deficient mouse brain
BACKGROUND: X11-family proteins, including X11, X11-like (X11L) and X11-like 2 (X11L2), bind to the cytoplasmic domain of amyloid β-protein precursor (APP) and regulate APP metabolism. Both X11 and X11L are expressed specifically in brain, while X11L2 is expressed ubiquitously. X11L is predominantly...
Autores principales: | Kondo, Maho, Shiono, Maki, Itoh, Genzo, Takei, Norio, Matsushima, Takahide, Maeda, Masahiro, Taru, Hidenori, Hata, Saori, Yamamoto, Tohru, Saito, Yuhki, Suzuki, Toshiharu |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949864/ https://www.ncbi.nlm.nih.gov/pubmed/20843325 http://dx.doi.org/10.1186/1750-1326-5-35 |
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