Concept and Management of Treatment Resistant Schizophrenia (TRS)

Treatment resistance in schizophrenia is a fairly common problem faced by psychiatrists worldwide. The concept and definition of Treatment Resistant Schizophrenia (TRS) is still far from satisfactory. Data suggests the presence of biological factors underlying TRS. Second generation antipsychotics a...

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Detalles Bibliográficos
Autores principales: Painuly, Nitesh, Gupta, Nitin, Avasthi, Ajit
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2004
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949927/
https://www.ncbi.nlm.nih.gov/pubmed/21408038
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author Painuly, Nitesh
Gupta, Nitin
Avasthi, Ajit
author_facet Painuly, Nitesh
Gupta, Nitin
Avasthi, Ajit
author_sort Painuly, Nitesh
collection PubMed
description Treatment resistance in schizophrenia is a fairly common problem faced by psychiatrists worldwide. The concept and definition of Treatment Resistant Schizophrenia (TRS) is still far from satisfactory. Data suggests the presence of biological factors underlying TRS. Second generation antipsychotics are advocated for patients with TRS. However, till date, clozapine remains the treatment of choice. Evidence for other pharmacological measures and ECT is accumulating. Psychosocial interventions do form an integral component of management of TRS. It can be concluded that, with advances in sychopharmacology, TRS needs to be better researched and managed in the future.
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spelling pubmed-29499272011-03-15 Concept and Management of Treatment Resistant Schizophrenia (TRS) Painuly, Nitesh Gupta, Nitin Avasthi, Ajit Indian J Psychiatry Review Article Treatment resistance in schizophrenia is a fairly common problem faced by psychiatrists worldwide. The concept and definition of Treatment Resistant Schizophrenia (TRS) is still far from satisfactory. Data suggests the presence of biological factors underlying TRS. Second generation antipsychotics are advocated for patients with TRS. However, till date, clozapine remains the treatment of choice. Evidence for other pharmacological measures and ECT is accumulating. Psychosocial interventions do form an integral component of management of TRS. It can be concluded that, with advances in sychopharmacology, TRS needs to be better researched and managed in the future. Medknow Publications 2004 /pmc/articles/PMC2949927/ /pubmed/21408038 Text en Copyright: © Indian Journal of Psychiatry http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Painuly, Nitesh
Gupta, Nitin
Avasthi, Ajit
Concept and Management of Treatment Resistant Schizophrenia (TRS)
title Concept and Management of Treatment Resistant Schizophrenia (TRS)
title_full Concept and Management of Treatment Resistant Schizophrenia (TRS)
title_fullStr Concept and Management of Treatment Resistant Schizophrenia (TRS)
title_full_unstemmed Concept and Management of Treatment Resistant Schizophrenia (TRS)
title_short Concept and Management of Treatment Resistant Schizophrenia (TRS)
title_sort concept and management of treatment resistant schizophrenia (trs)
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949927/
https://www.ncbi.nlm.nih.gov/pubmed/21408038
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