PRDM9 sticks its zinc fingers into recombination hotspots and between species

Meiotic recombination events typically cluster within narrow regions of the genome termed hotspots. A series of recent papers reveals that PRDM9, a C2H2-type zinc-finger protein with histone H3 lysine 4 methyltransferase activity, plays a major role in the specification of hotspots. The zinc fingers...

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Detalles Bibliográficos
Autores principales: Sandovici, Ionel, Sapienza, Carmen
Formato: Texto
Lenguaje:English
Publicado: Faculty of 1000 Ltd 2010
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950028/
https://www.ncbi.nlm.nih.gov/pubmed/20948797
http://dx.doi.org/10.3410/B2-37
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author Sandovici, Ionel
Sapienza, Carmen
author_facet Sandovici, Ionel
Sapienza, Carmen
author_sort Sandovici, Ionel
collection PubMed
description Meiotic recombination events typically cluster within narrow regions of the genome termed hotspots. A series of recent papers reveals that PRDM9, a C2H2-type zinc-finger protein with histone H3 lysine 4 methyltransferase activity, plays a major role in the specification of hotspots. The zinc fingers that contact DNA in a sequence-dependent manner evolve rapidly and are under positive selection, leading to differences in the location of recombination hotspots as well as hybrid sterility.
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spelling pubmed-29500282010-10-14 PRDM9 sticks its zinc fingers into recombination hotspots and between species Sandovici, Ionel Sapienza, Carmen F1000 Biol Rep Review Article Meiotic recombination events typically cluster within narrow regions of the genome termed hotspots. A series of recent papers reveals that PRDM9, a C2H2-type zinc-finger protein with histone H3 lysine 4 methyltransferase activity, plays a major role in the specification of hotspots. The zinc fingers that contact DNA in a sequence-dependent manner evolve rapidly and are under positive selection, leading to differences in the location of recombination hotspots as well as hybrid sterility. Faculty of 1000 Ltd 2010-05-24 /pmc/articles/PMC2950028/ /pubmed/20948797 http://dx.doi.org/10.3410/B2-37 Text en © 2010 Faculty of 1000 Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use this work for commercial purposes
spellingShingle Review Article
Sandovici, Ionel
Sapienza, Carmen
PRDM9 sticks its zinc fingers into recombination hotspots and between species
title PRDM9 sticks its zinc fingers into recombination hotspots and between species
title_full PRDM9 sticks its zinc fingers into recombination hotspots and between species
title_fullStr PRDM9 sticks its zinc fingers into recombination hotspots and between species
title_full_unstemmed PRDM9 sticks its zinc fingers into recombination hotspots and between species
title_short PRDM9 sticks its zinc fingers into recombination hotspots and between species
title_sort prdm9 sticks its zinc fingers into recombination hotspots and between species
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950028/
https://www.ncbi.nlm.nih.gov/pubmed/20948797
http://dx.doi.org/10.3410/B2-37
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