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Toxicity evaluation of Xanthorrhoea johnsonii leaf methanolic extract using the Artemia franciscana bioassay

The toxicity of Xanthorrhoea johnsonii methanolic leaf extract was investigated using the Artemia franciscana nauplii bioassay. At 24 h, the extract produced an EC(50) of 361.0 ± 41.8 μg/ml, indicating that it was substantially more toxic than the pesticide Mevinphos (1346.2 ± 80.1 μg/ml) and approx...

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Detalles Bibliográficos
Autores principales: Cock, I. E., Kalt, F. R.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950376/
https://www.ncbi.nlm.nih.gov/pubmed/20931073
http://dx.doi.org/10.4103/0973-1296.66929
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author Cock, I. E.
Kalt, F. R.
author_facet Cock, I. E.
Kalt, F. R.
author_sort Cock, I. E.
collection PubMed
description The toxicity of Xanthorrhoea johnsonii methanolic leaf extract was investigated using the Artemia franciscana nauplii bioassay. At 24 h, the extract produced an EC(50) of 361.0 ± 41.8 μg/ml, indicating that it was substantially more toxic than the pesticide Mevinphos (1346.2 ± 80.1 μg/ml) and approximately 4 fold less toxic than potassium dichromate (87.1 ± 5.2 μg/ml). Whilst potassium dichromate LC(50) values remained constant across the 72-h test period, these values decreased for the extract and Mevinphos to similar values (199.8 ± 60.5 and 114 ± 12.8 μg/ml, respectively), indicating their similar level of efficacy. Noteworthy was the apparent anesthetic effect of X. johnsonii leaf extract. Although the extract initially appeared to kill the A. franciscana nauplii, they were seen to temporarily recover by 48 h only to die by 72 h.
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spelling pubmed-29503762010-10-07 Toxicity evaluation of Xanthorrhoea johnsonii leaf methanolic extract using the Artemia franciscana bioassay Cock, I. E. Kalt, F. R. Pharmacogn Mag Original Article The toxicity of Xanthorrhoea johnsonii methanolic leaf extract was investigated using the Artemia franciscana nauplii bioassay. At 24 h, the extract produced an EC(50) of 361.0 ± 41.8 μg/ml, indicating that it was substantially more toxic than the pesticide Mevinphos (1346.2 ± 80.1 μg/ml) and approximately 4 fold less toxic than potassium dichromate (87.1 ± 5.2 μg/ml). Whilst potassium dichromate LC(50) values remained constant across the 72-h test period, these values decreased for the extract and Mevinphos to similar values (199.8 ± 60.5 and 114 ± 12.8 μg/ml, respectively), indicating their similar level of efficacy. Noteworthy was the apparent anesthetic effect of X. johnsonii leaf extract. Although the extract initially appeared to kill the A. franciscana nauplii, they were seen to temporarily recover by 48 h only to die by 72 h. Medknow Publications 2010 /pmc/articles/PMC2950376/ /pubmed/20931073 http://dx.doi.org/10.4103/0973-1296.66929 Text en © Pharmacognosy Magazine http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Cock, I. E.
Kalt, F. R.
Toxicity evaluation of Xanthorrhoea johnsonii leaf methanolic extract using the Artemia franciscana bioassay
title Toxicity evaluation of Xanthorrhoea johnsonii leaf methanolic extract using the Artemia franciscana bioassay
title_full Toxicity evaluation of Xanthorrhoea johnsonii leaf methanolic extract using the Artemia franciscana bioassay
title_fullStr Toxicity evaluation of Xanthorrhoea johnsonii leaf methanolic extract using the Artemia franciscana bioassay
title_full_unstemmed Toxicity evaluation of Xanthorrhoea johnsonii leaf methanolic extract using the Artemia franciscana bioassay
title_short Toxicity evaluation of Xanthorrhoea johnsonii leaf methanolic extract using the Artemia franciscana bioassay
title_sort toxicity evaluation of xanthorrhoea johnsonii leaf methanolic extract using the artemia franciscana bioassay
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950376/
https://www.ncbi.nlm.nih.gov/pubmed/20931073
http://dx.doi.org/10.4103/0973-1296.66929
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