Behavioral Changes as the Earliest Clinical Manifestation of Progressive Supranuclear Palsy

BACKGROUND: The clinical and pathological heterogeneity of progressive supranuclear palsy (PSP) is well established. Even with a well-defined clinical phenotype and a thorough laboratory workup, PSP can be misdiagnosed, especially in its early stages. CASE REPORT: A 52-year-old woman, who we initial...

Descripción completa

Detalles Bibliográficos
Autores principales: Han, Hyun Jeong, Kim, Hyeyun, Park, Jong-Ho, Shin, Hyung-Woo, Kim, Go Un, Kim, Dong Sun, Lee, Eun Ja, Oh, Hwa Eun, Park, Seung-Hye, Kim, Yun Jung
Formato: Texto
Lenguaje:English
Publicado: Korean Neurological Association 2010
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950920/
https://www.ncbi.nlm.nih.gov/pubmed/20944816
http://dx.doi.org/10.3988/jcn.2010.6.3.148
Descripción
Sumario:BACKGROUND: The clinical and pathological heterogeneity of progressive supranuclear palsy (PSP) is well established. Even with a well-defined clinical phenotype and a thorough laboratory workup, PSP can be misdiagnosed, especially in its early stages. CASE REPORT: A 52-year-old woman, who we initially diagnosed with a behavioral variant of frontotemporal dementia developed parkinsonian features, which then progressed to gait instability and gaze abnormality. CONCLUSIONS: We report herein a pathologically confirmed case of PSP presenting with behavioral changes including agitation and irritability, which eventually led to the cardinal symptoms of progressive supranuclear palsy.

Ejemplares similares