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Distension-Induced Gastric Contraction is Attenuated in an Experimental Model of Gastric Restraint

BACKGROUND: Gastric distension has important implications for motility and satiety. The hypothesis of this study was that distension affects the amplitude and duration of gastric contraction and that these parameters are largely mediated by efferent vagus stimulation. METHODS: A novel isovolumic myo...

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Autores principales: Lu, Xiao, Guo, Xiaomei, Mattar, Samer G., Navia, Jose A., Kassab, Ghassan S.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950927/
https://www.ncbi.nlm.nih.gov/pubmed/20706803
http://dx.doi.org/10.1007/s11695-010-0240-x
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author Lu, Xiao
Guo, Xiaomei
Mattar, Samer G.
Navia, Jose A.
Kassab, Ghassan S.
author_facet Lu, Xiao
Guo, Xiaomei
Mattar, Samer G.
Navia, Jose A.
Kassab, Ghassan S.
author_sort Lu, Xiao
collection PubMed
description BACKGROUND: Gastric distension has important implications for motility and satiety. The hypothesis of this study was that distension affects the amplitude and duration of gastric contraction and that these parameters are largely mediated by efferent vagus stimulation. METHODS: A novel isovolumic myograph was introduced to test these hypotheses. The isovolumic myograph isolates the stomach and records the pressure generated by the gastric contraction under isovolumic conditions. Accordingly, the phasic changes of gastric contractility can be documented. A group of 12 rats were used under in vivo conditions and isolated ex vivo conditions and with two different gastric restraints (small and large) to determine the effect of degree of restraint. RESULTS: The comparison of the in vivo and ex vivo contractility provided information on the efferent vagus mediation of gastric contraction, i.e., the in vivo amplitude and duration reached maximum of 12.6 ± 2.7 mmHg and 19.8 ± 5.6 s in contrast to maximum of 5.7 ± 0.9 mmHg and 7.3 ± 1.3 s in ex vivo amplitude and duration, respectively. The comparison of gastric restraint and control groups highlights the role of distension on in vivo gastric contractility. The limitation of gastric distension by restraint drastically reduced the maximal amplitude to below 2.9 ± 0.2 mmHg. CONCLUSIONS: The results show that distension-induced gastric contractility is regulated by both central nervous system and local mechanisms with the former being more substantial. Furthermore, the gastric restraint significantly attenuates gastric contractility (decreased amplitude and shortened duration of contraction) which is mediated by the efferent vagus activation. These findings have important implications for gastric motility and physiology and may improve our understanding of satiety.
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spelling pubmed-29509272010-10-21 Distension-Induced Gastric Contraction is Attenuated in an Experimental Model of Gastric Restraint Lu, Xiao Guo, Xiaomei Mattar, Samer G. Navia, Jose A. Kassab, Ghassan S. Obes Surg Basic Science Research BACKGROUND: Gastric distension has important implications for motility and satiety. The hypothesis of this study was that distension affects the amplitude and duration of gastric contraction and that these parameters are largely mediated by efferent vagus stimulation. METHODS: A novel isovolumic myograph was introduced to test these hypotheses. The isovolumic myograph isolates the stomach and records the pressure generated by the gastric contraction under isovolumic conditions. Accordingly, the phasic changes of gastric contractility can be documented. A group of 12 rats were used under in vivo conditions and isolated ex vivo conditions and with two different gastric restraints (small and large) to determine the effect of degree of restraint. RESULTS: The comparison of the in vivo and ex vivo contractility provided information on the efferent vagus mediation of gastric contraction, i.e., the in vivo amplitude and duration reached maximum of 12.6 ± 2.7 mmHg and 19.8 ± 5.6 s in contrast to maximum of 5.7 ± 0.9 mmHg and 7.3 ± 1.3 s in ex vivo amplitude and duration, respectively. The comparison of gastric restraint and control groups highlights the role of distension on in vivo gastric contractility. The limitation of gastric distension by restraint drastically reduced the maximal amplitude to below 2.9 ± 0.2 mmHg. CONCLUSIONS: The results show that distension-induced gastric contractility is regulated by both central nervous system and local mechanisms with the former being more substantial. Furthermore, the gastric restraint significantly attenuates gastric contractility (decreased amplitude and shortened duration of contraction) which is mediated by the efferent vagus activation. These findings have important implications for gastric motility and physiology and may improve our understanding of satiety. Springer-Verlag 2010-08-13 2010 /pmc/articles/PMC2950927/ /pubmed/20706803 http://dx.doi.org/10.1007/s11695-010-0240-x Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Basic Science Research
Lu, Xiao
Guo, Xiaomei
Mattar, Samer G.
Navia, Jose A.
Kassab, Ghassan S.
Distension-Induced Gastric Contraction is Attenuated in an Experimental Model of Gastric Restraint
title Distension-Induced Gastric Contraction is Attenuated in an Experimental Model of Gastric Restraint
title_full Distension-Induced Gastric Contraction is Attenuated in an Experimental Model of Gastric Restraint
title_fullStr Distension-Induced Gastric Contraction is Attenuated in an Experimental Model of Gastric Restraint
title_full_unstemmed Distension-Induced Gastric Contraction is Attenuated in an Experimental Model of Gastric Restraint
title_short Distension-Induced Gastric Contraction is Attenuated in an Experimental Model of Gastric Restraint
title_sort distension-induced gastric contraction is attenuated in an experimental model of gastric restraint
topic Basic Science Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950927/
https://www.ncbi.nlm.nih.gov/pubmed/20706803
http://dx.doi.org/10.1007/s11695-010-0240-x
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