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Impulsivity, gender, and the platelet serotonin transporter in healthy subjects

The present study explored the possible relationships between impulsivity, gender, and a peripheral serotonergic marker, the platelet serotonin (5-HT) transporter (SERT), in a group of 32 healthy subjects. The impulsivity was measured by means of the Barratt Impulsivity Scale, version 11 (BIS-11), a...

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Autores principales: Marazziti, Donatella, Baroni, Stefano, Masala, Irene, Golia, Francesca, Consoli, Giorgio, Massimetti, Gabriele, Picchetti, Michela, Dell’Osso, Mario Catena, Giannaccini, Gino, Betti, Laura, Lucacchini, Antonio, Ciapparelli, Antonio
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951061/
https://www.ncbi.nlm.nih.gov/pubmed/20169041
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author Marazziti, Donatella
Baroni, Stefano
Masala, Irene
Golia, Francesca
Consoli, Giorgio
Massimetti, Gabriele
Picchetti, Michela
Dell’Osso, Mario Catena
Giannaccini, Gino
Betti, Laura
Lucacchini, Antonio
Ciapparelli, Antonio
author_facet Marazziti, Donatella
Baroni, Stefano
Masala, Irene
Golia, Francesca
Consoli, Giorgio
Massimetti, Gabriele
Picchetti, Michela
Dell’Osso, Mario Catena
Giannaccini, Gino
Betti, Laura
Lucacchini, Antonio
Ciapparelli, Antonio
author_sort Marazziti, Donatella
collection PubMed
description The present study explored the possible relationships between impulsivity, gender, and a peripheral serotonergic marker, the platelet serotonin (5-HT) transporter (SERT), in a group of 32 healthy subjects. The impulsivity was measured by means of the Barratt Impulsivity Scale, version 11 (BIS-11), a widely used self-report questionnaire, and the platelet SERT was evaluated by means of the specific binding of (3)H-paroxetine ((3)H-Par) to platelet membranes, according to standardized protocols. The results showed that women had a higher BIS-11 total score than men, and also higher scores of two factors of the same scale: the motor impulsivity and the cognitive complexity. The analysis of the correlations revealed that the density of the SERT proteins, as measured by the maximum binding capacity (B(max)) of (3)H-Par, was significantly and positively related to the cognitive complexity factor, but only in men. Men showed also a significant and negative correlation with the dissociation constant, Kd, of ((3)H-Par) binding, and the motor impulsivity factor. These findings suggest that women are generally more impulsive than men, but that the 5-HT system is more involved in the impulsivity of men than in that of women.
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spelling pubmed-29510612011-12-14 Impulsivity, gender, and the platelet serotonin transporter in healthy subjects Marazziti, Donatella Baroni, Stefano Masala, Irene Golia, Francesca Consoli, Giorgio Massimetti, Gabriele Picchetti, Michela Dell’Osso, Mario Catena Giannaccini, Gino Betti, Laura Lucacchini, Antonio Ciapparelli, Antonio Neuropsychiatr Dis Treat Original Research The present study explored the possible relationships between impulsivity, gender, and a peripheral serotonergic marker, the platelet serotonin (5-HT) transporter (SERT), in a group of 32 healthy subjects. The impulsivity was measured by means of the Barratt Impulsivity Scale, version 11 (BIS-11), a widely used self-report questionnaire, and the platelet SERT was evaluated by means of the specific binding of (3)H-paroxetine ((3)H-Par) to platelet membranes, according to standardized protocols. The results showed that women had a higher BIS-11 total score than men, and also higher scores of two factors of the same scale: the motor impulsivity and the cognitive complexity. The analysis of the correlations revealed that the density of the SERT proteins, as measured by the maximum binding capacity (B(max)) of (3)H-Par, was significantly and positively related to the cognitive complexity factor, but only in men. Men showed also a significant and negative correlation with the dissociation constant, Kd, of ((3)H-Par) binding, and the motor impulsivity factor. These findings suggest that women are generally more impulsive than men, but that the 5-HT system is more involved in the impulsivity of men than in that of women. Dove Medical Press 2010 2010-02-03 /pmc/articles/PMC2951061/ /pubmed/20169041 Text en © 2010 Marazziti et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Marazziti, Donatella
Baroni, Stefano
Masala, Irene
Golia, Francesca
Consoli, Giorgio
Massimetti, Gabriele
Picchetti, Michela
Dell’Osso, Mario Catena
Giannaccini, Gino
Betti, Laura
Lucacchini, Antonio
Ciapparelli, Antonio
Impulsivity, gender, and the platelet serotonin transporter in healthy subjects
title Impulsivity, gender, and the platelet serotonin transporter in healthy subjects
title_full Impulsivity, gender, and the platelet serotonin transporter in healthy subjects
title_fullStr Impulsivity, gender, and the platelet serotonin transporter in healthy subjects
title_full_unstemmed Impulsivity, gender, and the platelet serotonin transporter in healthy subjects
title_short Impulsivity, gender, and the platelet serotonin transporter in healthy subjects
title_sort impulsivity, gender, and the platelet serotonin transporter in healthy subjects
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951061/
https://www.ncbi.nlm.nih.gov/pubmed/20169041
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