In vitro expression of NGN3 identifies RAB3B as the predominant Ras-associated GTP-binding protein 3 family member in human islets

Neurogenin 3 (NGN3) commits pancreatic progenitors to an islet cell fate. We have induced NGN3 expression and identified upregulation of the gene encoding the Ras-associated small molecular mass GTP-binding protein, RAB3B. RAB3B localised to the cytoplasm of human β-cells, both during the foetal per...

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Detalles Bibliográficos
Autores principales: Piper Hanley, Karen, Hearn, Tom, Berry, Andrew, Carvell, Melanie J, Patch, Ann-Marie, Williams, Louise J, Sugden, Sarah A, Wilson, David I, Ellard, Sian, Hanley, Neil A
Formato: Texto
Lenguaje:English
Publicado: BioScientifica 2010
Materias:
Regular Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951179/
https://www.ncbi.nlm.nih.gov/pubmed/20807725
http://dx.doi.org/10.1677/JOE-10-0120

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