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Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres
During replicative aging of primary cells morphological transformations occur, the expression pattern is altered and chromatin changes globally. Here we show that chronic damage signals, likely caused by telomere processing, impact expression of histones and lead to their depletion. Interrogation of...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951278/ https://www.ncbi.nlm.nih.gov/pubmed/20890289 http://dx.doi.org/10.1038/nsmb.1897 |