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Solution Structure and Dynamics of the I214V Mutant of the Rabbit Prion Protein

BACKGROUND: The conformational conversion of the host-derived cellular prion protein (PrP(C)) into the disease-associated scrapie isoform (PrP(Sc)) is responsible for the pathogenesis of transmissible spongiform encephalopathies (TSEs). Various single-point mutations in PrP(C)s could cause structura...

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Detalles Bibliográficos
Autores principales:	Wen, Yi, Li, Jun, Xiong, Minqian, Peng, Yu, Yao, Wenming, Hong, Jing, Lin, Donghai
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951349/ https://www.ncbi.nlm.nih.gov/pubmed/20949107 http://dx.doi.org/10.1371/journal.pone.0013273

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