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Post-seizure EEG fractal dimension and spectral power predict antidepressant response to unilateral ECT

BACKGROUND: Measures of EEG during ECT, for example, smaller post-seizure fractal dimension have predicted antidepressant response. The earlier study on this subject used bilateral ECT. This study aims to examine if this finding holds good even for unilateral ECT, using both fractal dimension and sp...

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Autores principales: Jagadisha, Gangadhar, BN, Janakiramiah, N, Girish, K, Ramakrishnan, AG
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951533/
https://www.ncbi.nlm.nih.gov/pubmed/21206807
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author Jagadisha,
Gangadhar, BN
Janakiramiah, N
Girish, K
Ramakrishnan, AG
author_facet Jagadisha,
Gangadhar, BN
Janakiramiah, N
Girish, K
Ramakrishnan, AG
author_sort Jagadisha,
collection PubMed
description BACKGROUND: Measures of EEG during ECT, for example, smaller post-seizure fractal dimension have predicted antidepressant response. The earlier study on this subject used bilateral ECT. This study aims to examine if this finding holds good even for unilateral ECT, using both fractal dimension and spectral power analysis of EEG. METHODS: Fifty-one right-handed, drug-free patients with major depressive disorder received right unilateral ECTs at 2.5 times their seizure threshold. A rater blind to the clinical data measured fractal dimension and spectral power of EEG during their second ECT. Depression was rated using Hamilton′s Rating Scale for Depression at baseline and on the 3rd, 7th and 14th days following ECT. RESULTS: Thirty-five good quality EEG recordings were analyzed. Seventeen patients reached criteria for early response of more than median percent improvement on HRSD on both 7th and 14th day. Univariate analysis showed smaller fractal dimension and spectral power (greater post-seizure EEG suppression) in early responders compared to the late responders. This was confirmed by multivariate discriminant function analysis. None of the other clinical, treatment or EEG parameters predicted early response. CONCLUSIONS: Effective seizure during unilateral ECT may be characterized by high post-seizure EEG suppression.
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spelling pubmed-29515332011-01-04 Post-seizure EEG fractal dimension and spectral power predict antidepressant response to unilateral ECT Jagadisha, Gangadhar, BN Janakiramiah, N Girish, K Ramakrishnan, AG Indian J Psychiatry Award Paper BACKGROUND: Measures of EEG during ECT, for example, smaller post-seizure fractal dimension have predicted antidepressant response. The earlier study on this subject used bilateral ECT. This study aims to examine if this finding holds good even for unilateral ECT, using both fractal dimension and spectral power analysis of EEG. METHODS: Fifty-one right-handed, drug-free patients with major depressive disorder received right unilateral ECTs at 2.5 times their seizure threshold. A rater blind to the clinical data measured fractal dimension and spectral power of EEG during their second ECT. Depression was rated using Hamilton′s Rating Scale for Depression at baseline and on the 3rd, 7th and 14th days following ECT. RESULTS: Thirty-five good quality EEG recordings were analyzed. Seventeen patients reached criteria for early response of more than median percent improvement on HRSD on both 7th and 14th day. Univariate analysis showed smaller fractal dimension and spectral power (greater post-seizure EEG suppression) in early responders compared to the late responders. This was confirmed by multivariate discriminant function analysis. None of the other clinical, treatment or EEG parameters predicted early response. CONCLUSIONS: Effective seizure during unilateral ECT may be characterized by high post-seizure EEG suppression. Medknow Publications 2003 /pmc/articles/PMC2951533/ /pubmed/21206807 Text en Copyright: © Indian Journal of Psychiatry http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Award Paper
Jagadisha,
Gangadhar, BN
Janakiramiah, N
Girish, K
Ramakrishnan, AG
Post-seizure EEG fractal dimension and spectral power predict antidepressant response to unilateral ECT
title Post-seizure EEG fractal dimension and spectral power predict antidepressant response to unilateral ECT
title_full Post-seizure EEG fractal dimension and spectral power predict antidepressant response to unilateral ECT
title_fullStr Post-seizure EEG fractal dimension and spectral power predict antidepressant response to unilateral ECT
title_full_unstemmed Post-seizure EEG fractal dimension and spectral power predict antidepressant response to unilateral ECT
title_short Post-seizure EEG fractal dimension and spectral power predict antidepressant response to unilateral ECT
title_sort post-seizure eeg fractal dimension and spectral power predict antidepressant response to unilateral ect
topic Award Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951533/
https://www.ncbi.nlm.nih.gov/pubmed/21206807
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