Olanzapine Induced Mania: A Case Report

A 35 yrs, old male, a known case of Paranoid Schizophrenia for last 20 yrs, not respond to conventional anti-psychotics and was prescribed Olanzapine upto to 30mg/day. Patient developed manic symptoms during olanzapine therapy. He also showed a strong desire or sense of compu′sion to take the substance and progressive neglect of alternative pleasurable activities and fulfilled the criteria for dependence syndrome as per ICD-10 (WHO, 1992). This is a rare case of olanzapine induced mania along with abuse of olanzapine. This is suggested that during treatment with Olanzapine, the clinicians should be vigilant for mood changes and risk of olanzapine abuse.