The microarray manual curation tool (MMCT): A Web server for microarray probe evaluations

Quality control of probe sequences is a major concern in microarray technology. The presence of poor quality probes has a negative impact on the microarray data analysis process. The Microarray Manual Curation Tool (MMCT) is a web server application that provides computational and visual means to in...

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Detalles Bibliográficos
Autores principales: Tulpan, Dan, Belliveau, Luc, Léger, Serge
Formato: Texto
Lenguaje:English
Publicado: Biomedical Informatics Publishing Group 2010
Materias:
Web Server
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951669/
https://www.ncbi.nlm.nih.gov/pubmed/20975897
Descripción
Sumario:Quality control of probe sequences is a major concern in microarray technology. The presence of poor quality probes has a negative impact on the microarray data analysis process. The Microarray Manual Curation Tool (MMCT) is a web server application that provides computational and visual means to investigate the quality of individual probes for oligo microarrays. The MMCT quality metrics assess the free energy of hybridization and the secondary structure of duplexes formed by selected targets and probes, which are specific to various microarray platforms. AVAILABILITY: http://www.nrcbioinformatics.ca/mmct

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