Clustering tendency in the protein fold space

Several non-redundant ensembles of protein three-dimensional structures were analyzed in order to estimate their natural clustering tendency by means of the Cox-Lewis coefficient. It was observed that, despite proteins tend to aggregate into different and well separated groups, some overlap between...

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Detalles Bibliográficos
Autor principal: Carugo, Oliviero
Formato: Texto
Lenguaje:English
Publicado: Biomedical Informatics Publishing Group 2010
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951670/
https://www.ncbi.nlm.nih.gov/pubmed/20975898
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author Carugo, Oliviero
author_facet Carugo, Oliviero
author_sort Carugo, Oliviero
collection PubMed
description Several non-redundant ensembles of protein three-dimensional structures were analyzed in order to estimate their natural clustering tendency by means of the Cox-Lewis coefficient. It was observed that, despite proteins tend to aggregate into different and well separated groups, some overlap between different clusters occurs. This suggests that classifications bases only on structural data cannot allow a systematic classification of proteins. Additional information are in particular needed in order to monitor completely the complex evolutionary relationships between proteins.
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spelling pubmed-29516702010-10-25 Clustering tendency in the protein fold space Carugo, Oliviero Bioinformation Hypothesis Several non-redundant ensembles of protein three-dimensional structures were analyzed in order to estimate their natural clustering tendency by means of the Cox-Lewis coefficient. It was observed that, despite proteins tend to aggregate into different and well separated groups, some overlap between different clusters occurs. This suggests that classifications bases only on structural data cannot allow a systematic classification of proteins. Additional information are in particular needed in order to monitor completely the complex evolutionary relationships between proteins. Biomedical Informatics Publishing Group 2010-02-28 /pmc/articles/PMC2951670/ /pubmed/20975898 Text en © 2010 Biomedical Informatics Publishing Group This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium, for non-commercial purposes, provided the original author and source are credited.
spellingShingle Hypothesis
Carugo, Oliviero
Clustering tendency in the protein fold space
title Clustering tendency in the protein fold space
title_full Clustering tendency in the protein fold space
title_fullStr Clustering tendency in the protein fold space
title_full_unstemmed Clustering tendency in the protein fold space
title_short Clustering tendency in the protein fold space
title_sort clustering tendency in the protein fold space
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951670/
https://www.ncbi.nlm.nih.gov/pubmed/20975898
work_keys_str_mv AT carugooliviero clusteringtendencyintheproteinfoldspace

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