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Origin of Active States in Local Neocortical Networks during Slow Sleep Oscillation

Slow-wave sleep is characterized by spontaneous alternations of activity and silence in corticothalamic networks, but the causes of transition from silence to activity remain unknown. We investigated local mechanisms underlying initiation of activity, using simultaneous multisite field potential, mu...

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Detalles Bibliográficos
Autores principales: Chauvette, Sylvain, Volgushev, Maxim, Timofeev, Igor
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951844/
https://www.ncbi.nlm.nih.gov/pubmed/20200108
http://dx.doi.org/10.1093/cercor/bhq009
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author Chauvette, Sylvain
Volgushev, Maxim
Timofeev, Igor
author_facet Chauvette, Sylvain
Volgushev, Maxim
Timofeev, Igor
author_sort Chauvette, Sylvain
collection PubMed
description Slow-wave sleep is characterized by spontaneous alternations of activity and silence in corticothalamic networks, but the causes of transition from silence to activity remain unknown. We investigated local mechanisms underlying initiation of activity, using simultaneous multisite field potential, multiunit recordings, and intracellular recordings from 2 to 4 nearby neurons in naturally sleeping or anesthetized cats. We demonstrate that activity may start in any neuron or recording location, with tens of milliseconds delay in other cells and sites. Typically, however, activity originated at deep locations, then involved some superficial cells, but appeared later in the middle of the cortex. Neuronal firing was also found to begin, after the onset of active states, at depths that correspond to cortical layer V. These results support the hypothesis that switch from silence to activity is mediated by spontaneous synaptic events, whereby any neuron may become active first. Due to probabilistic nature of activity onset, the large pyramidal cells from deep cortical layers, which are equipped with the most numerous synaptic inputs and large projection fields, are best suited for switching the whole network into active state.
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spelling pubmed-29518442010-10-12 Origin of Active States in Local Neocortical Networks during Slow Sleep Oscillation Chauvette, Sylvain Volgushev, Maxim Timofeev, Igor Cereb Cortex Articles Slow-wave sleep is characterized by spontaneous alternations of activity and silence in corticothalamic networks, but the causes of transition from silence to activity remain unknown. We investigated local mechanisms underlying initiation of activity, using simultaneous multisite field potential, multiunit recordings, and intracellular recordings from 2 to 4 nearby neurons in naturally sleeping or anesthetized cats. We demonstrate that activity may start in any neuron or recording location, with tens of milliseconds delay in other cells and sites. Typically, however, activity originated at deep locations, then involved some superficial cells, but appeared later in the middle of the cortex. Neuronal firing was also found to begin, after the onset of active states, at depths that correspond to cortical layer V. These results support the hypothesis that switch from silence to activity is mediated by spontaneous synaptic events, whereby any neuron may become active first. Due to probabilistic nature of activity onset, the large pyramidal cells from deep cortical layers, which are equipped with the most numerous synaptic inputs and large projection fields, are best suited for switching the whole network into active state. Oxford University Press 2010-11 2010-03-03 /pmc/articles/PMC2951844/ /pubmed/20200108 http://dx.doi.org/10.1093/cercor/bhq009 Text en © The Authors 2010. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Chauvette, Sylvain
Volgushev, Maxim
Timofeev, Igor
Origin of Active States in Local Neocortical Networks during Slow Sleep Oscillation
title Origin of Active States in Local Neocortical Networks during Slow Sleep Oscillation
title_full Origin of Active States in Local Neocortical Networks during Slow Sleep Oscillation
title_fullStr Origin of Active States in Local Neocortical Networks during Slow Sleep Oscillation
title_full_unstemmed Origin of Active States in Local Neocortical Networks during Slow Sleep Oscillation
title_short Origin of Active States in Local Neocortical Networks during Slow Sleep Oscillation
title_sort origin of active states in local neocortical networks during slow sleep oscillation
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951844/
https://www.ncbi.nlm.nih.gov/pubmed/20200108
http://dx.doi.org/10.1093/cercor/bhq009
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