Staphylococcal Peptidoglycan Co-Localizes with Nod2 and TLR2 and Activates Innate Immune Response via Both Receptors in Primary Murine Keratinocytes

In mammalian host cells staphylococcal peptidoglycan (PGN) is recognized by Nod2. Whether PGN is also recognized by TLR2 is disputed. Here we carried out PGN co-localization and stimulation studies with TLR2 and Nod2 in wild type and mutant host cells. To exclude contamination with lipoproteins, pol...

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Detalles Bibliográficos
Autores principales: Müller-Anstett, Maria Anna, Müller, Patrick, Albrecht, Till, Nega, Mulugeta, Wagener, Jeanette, Gao, Qiang, Kaesler, Susanne, Schaller, Martin, Biedermann, Tilo, Götz, Friedrich
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951902/
https://www.ncbi.nlm.nih.gov/pubmed/20949035
http://dx.doi.org/10.1371/journal.pone.0013153

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