Passive neutralizing antibody controls SHIV viremia and enhances B cell responses in infant macaques

Maternal HIV-1-specific antibodies are efficiently transferred to newborns; their role in disease control is unknown. We administered non-sterilizing levels of neutralizing IgG, including the human neutralizing monoclonal IgG1b12, to six newborn macaques before oral challenge with SHIV(SF612P3). All...

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Autores principales: Ng, Cherie T., Jaworski, J. Pablo, Jayaraman, Pushpa, Sutton, William F., Delio, Patrick, Kuller, LaRene, Anderson, David, Landucci, Gary, Richardson, Barbra A., Burton, Dennis R., Forthal, Donald N., Haigwood, Nancy L.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952052/
https://www.ncbi.nlm.nih.gov/pubmed/20890292
http://dx.doi.org/10.1038/nm.2233
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author Ng, Cherie T.
Jaworski, J. Pablo
Jayaraman, Pushpa
Sutton, William F.
Delio, Patrick
Kuller, LaRene
Anderson, David
Landucci, Gary
Richardson, Barbra A.
Burton, Dennis R.
Forthal, Donald N.
Haigwood, Nancy L.
author_facet Ng, Cherie T.
Jaworski, J. Pablo
Jayaraman, Pushpa
Sutton, William F.
Delio, Patrick
Kuller, LaRene
Anderson, David
Landucci, Gary
Richardson, Barbra A.
Burton, Dennis R.
Forthal, Donald N.
Haigwood, Nancy L.
author_sort Ng, Cherie T.
collection PubMed
description Maternal HIV-1-specific antibodies are efficiently transferred to newborns; their role in disease control is unknown. We administered non-sterilizing levels of neutralizing IgG, including the human neutralizing monoclonal IgG1b12, to six newborn macaques before oral challenge with SHIV(SF612P3). All rapidly developed neutralizing antibodies and had significantly reduced plasma viremia for 6 months. These studies support the use of neutralizing antibodies in enhancing B cell responses and viral control in perinatal settings.
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spelling pubmed-29520522011-04-03 Passive neutralizing antibody controls SHIV viremia and enhances B cell responses in infant macaques Ng, Cherie T. Jaworski, J. Pablo Jayaraman, Pushpa Sutton, William F. Delio, Patrick Kuller, LaRene Anderson, David Landucci, Gary Richardson, Barbra A. Burton, Dennis R. Forthal, Donald N. Haigwood, Nancy L. Nat Med Article Maternal HIV-1-specific antibodies are efficiently transferred to newborns; their role in disease control is unknown. We administered non-sterilizing levels of neutralizing IgG, including the human neutralizing monoclonal IgG1b12, to six newborn macaques before oral challenge with SHIV(SF612P3). All rapidly developed neutralizing antibodies and had significantly reduced plasma viremia for 6 months. These studies support the use of neutralizing antibodies in enhancing B cell responses and viral control in perinatal settings. 2010-10-03 2010-10 /pmc/articles/PMC2952052/ /pubmed/20890292 http://dx.doi.org/10.1038/nm.2233 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Ng, Cherie T.
Jaworski, J. Pablo
Jayaraman, Pushpa
Sutton, William F.
Delio, Patrick
Kuller, LaRene
Anderson, David
Landucci, Gary
Richardson, Barbra A.
Burton, Dennis R.
Forthal, Donald N.
Haigwood, Nancy L.
Passive neutralizing antibody controls SHIV viremia and enhances B cell responses in infant macaques
title Passive neutralizing antibody controls SHIV viremia and enhances B cell responses in infant macaques
title_full Passive neutralizing antibody controls SHIV viremia and enhances B cell responses in infant macaques
title_fullStr Passive neutralizing antibody controls SHIV viremia and enhances B cell responses in infant macaques
title_full_unstemmed Passive neutralizing antibody controls SHIV viremia and enhances B cell responses in infant macaques
title_short Passive neutralizing antibody controls SHIV viremia and enhances B cell responses in infant macaques
title_sort passive neutralizing antibody controls shiv viremia and enhances b cell responses in infant macaques
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952052/
https://www.ncbi.nlm.nih.gov/pubmed/20890292
http://dx.doi.org/10.1038/nm.2233
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